Kinetics of conformational sampling in ubiquitin

David Ban, Michael Funk, Rudolf Gulich, Dalia Egger, T. Michael Sabo, Korvin F.A. Walter, R. Bryn Fenwick, Karin Giller, Fabio Pichierri, Bert L. Degroot, Oliver F. Lange, Helmut Grubmüller, Xavier Salvatella, Martin Wolf, Alois Loidl, Reiner Kree, Stefan Becker, Nils Alexander Lakomek, Donghan Lee, Peter LunkenheimerChristian Griesinger

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)


A good combination: The lifetime of interconversion among the ground states of a protein ensemble representation could only be assigned to a time window that is four orders of magnitude large and ranges from 4ns to 50 s. By combining temperature-dependent NMR relaxation dispersion (RD) experiments and dielectric relaxation (DR) spectroscopy in solution, the lifetime was now identified to a value of (10±9) s at 309K.

Original languageEnglish
Pages (from-to)11437-11440
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number48
Publication statusPublished - 2011 Nov 25


  • NMR spectroscopy
  • dielectric spectroscopy
  • kinetics
  • proteins
  • relaxation dispersion


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