KSRP/FUBP2 is a binding protein of GO-Y086, a cytotoxic curcumin analogue

Hiroyuki Yamakoshi, Naoki Kanoh, Chieko Kudo, Atsuko Sato, Kazunori Ueda, Makoto Muroi, Shunsuke Kon, Masanobu Satake, Hisatsugu Ohori, Chikashi Ishioka, Yoshiteru Oshima, Hiroyuki Osada, Natsuko Chiba, Hiroyuki Shibata, Yoshiharu Iwabuchi

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Bis(arylmethylidene)acetone derivatives are an important class of curcumin analogues that exhibit various biological and pharmacological activities. We herein report that GO-Y086, a biotinylated bis(arylmethylidene)acetone, inhibits cancer cell growth. We also show that GO-Y086 specifically interacts with the nuclear protein KSRP/FUBP2 by covalent modification. GO-Y086 markedly suppresses the expression of the c-Myc protein, which plays an important role in cellular proliferation and whose expression is regulated by KSRP/FUBP2.

Original languageEnglish
Pages (from-to)273-276
Number of pages4
JournalACS Medicinal Chemistry Letters
Issue number6
Publication statusPublished - 2010 Sept 9


  • anticancer
  • bis(arylmethylidene) acetone
  • c-Myc
  • curcumin analogue
  • target protein


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