TY - JOUR
T1 - Lecithin
T2 - Cholesterol acyltransferase is insufficient to prevent oxidative modification of low-density lipoprotein
AU - Murakami, Youhei
AU - Kamiyama, Shin
AU - Howlader, Zakir H.
AU - Yamato, Tokuhisa
AU - Komai, Michio
AU - Furukawa, Yuji
PY - 2002
Y1 - 2002
N2 - We tried to confirm the antioxidative capability of lecithin:cholesterol acyltransferase (LCAT) reported by Vohl et al. [Biochemistry (1999) 38, 5976-5981]. The enzyme solution protected LDL against oxidation. However, this protection was not due to LCAT enzyme, but to some unknown low-molecular-weight substance(s) in the solution; LCAT itself exerted little protective effect against LDL oxidation.
AB - We tried to confirm the antioxidative capability of lecithin:cholesterol acyltransferase (LCAT) reported by Vohl et al. [Biochemistry (1999) 38, 5976-5981]. The enzyme solution protected LDL against oxidation. However, this protection was not due to LCAT enzyme, but to some unknown low-molecular-weight substance(s) in the solution; LCAT itself exerted little protective effect against LDL oxidation.
KW - Antioxidation
KW - High-density lipoprotein
KW - Lecithin:cholesterol acyltransferase
KW - Low-density lipoprotein
KW - Oxidation
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U2 - 10.1093/oxfordjournals.jbchem.a003072
DO - 10.1093/oxfordjournals.jbchem.a003072
M3 - Article
C2 - 11754730
AN - SCOPUS:0036172686
SN - 0021-924X
VL - 131
SP - 17
EP - 19
JO - Journal of Biochemistry
JF - Journal of Biochemistry
IS - 1
ER -