TY - JOUR
T1 - Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels as a Biomarker of Acute Intracerebral Hemorrhage
AU - Inoue, Takashi
AU - Ishida, Tomohisa
AU - Inoue, Tomoo
AU - Saito, Atsushi
AU - Ezura, Masayuki
AU - Uenohara, Hiroshi
AU - Fujimura, Miki
AU - Sato, Kenichi
AU - Endo, Toshiki
AU - Omodaka, Shunsuke
AU - Endo, Hidenori
AU - Niizuma, Kuniyasu
AU - Tominaga, Teiji
N1 - Funding Information:
Sources of Funding: This work was supported by Grants-in-Aid for Scientific Research (KAKENHI No. 24592112) provided by the Japan Society for the Promotion of Science.
Publisher Copyright:
© 2018
PY - 2019/2
Y1 - 2019/2
N2 - Background: Correct diagnosis of cerebral stroke type, hemorrhagic or ischemic, is essential in the early stage to establish the optimum treatment. The diagnosis is mainly determined based on imaging studies. Other more available diagnostic methods are desirable, such as blood sample examination. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is very important in vascular dysfunction induced by oxidized low-density lipoprotein, including cell apoptosis. The present study evaluated LOX-1 as a biomarker for cerebral stroke. Subjects and Methods: Patients with newly diagnosed stroke were prospectively enrolled between February and July 2014. LOX-1 serum values were measured twice, within 24 hours and 2 months after the onset. Results: A total of 16 patients were enrolled; 7 patients with intracerebral hemorrhage (ICH) and 9 patients with cerebral infarction. Median LOX-1 values of patients with ICH and infarction in the acute phase were 1825.8 and 593.9 pg/mL, respectively, significantly higher in patients with ICH than in patients with infarction (P <.0001). Conclusion: LOX-1 serum level has potential as a biomarker of ICH.
AB - Background: Correct diagnosis of cerebral stroke type, hemorrhagic or ischemic, is essential in the early stage to establish the optimum treatment. The diagnosis is mainly determined based on imaging studies. Other more available diagnostic methods are desirable, such as blood sample examination. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is very important in vascular dysfunction induced by oxidized low-density lipoprotein, including cell apoptosis. The present study evaluated LOX-1 as a biomarker for cerebral stroke. Subjects and Methods: Patients with newly diagnosed stroke were prospectively enrolled between February and July 2014. LOX-1 serum values were measured twice, within 24 hours and 2 months after the onset. Results: A total of 16 patients were enrolled; 7 patients with intracerebral hemorrhage (ICH) and 9 patients with cerebral infarction. Median LOX-1 values of patients with ICH and infarction in the acute phase were 1825.8 and 593.9 pg/mL, respectively, significantly higher in patients with ICH than in patients with infarction (P <.0001). Conclusion: LOX-1 serum level has potential as a biomarker of ICH.
KW - Biomarker
KW - Diagnosis
KW - Diagnostic testing
KW - Intracranial hemorrhage
KW - intracerebral hemorrhage
KW - lectin-like oxidized low-density lipoprotein receptor-1
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U2 - 10.1016/j.jstrokecerebrovasdis.2018.10.027
DO - 10.1016/j.jstrokecerebrovasdis.2018.10.027
M3 - Article
C2 - 30442557
AN - SCOPUS:85056359985
SN - 1052-3057
VL - 28
SP - 490
EP - 494
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
IS - 2
ER -