Ligand-directed selective protein modification based on local single-electron-transfer catalysis

Shinichi Sato; Hiroyuki Nakamura

doi:10.1002/anie.201303831

Ligand-directed selective protein modification based on local single-electron-transfer catalysis

Shinichi Sato, Hiroyuki Nakamura

FRIS - Core Interdisciplinary Research Section

Gakushuin University

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Abstract

A photocatalyst ([Ru(bpy)₃]²⁺) bound to a protein ligand was essential for the title method. Local single-electron transfer from the catalyst resulted in the formation of tyrosyl radicals. N′-Acetyl-N,N- dimethyl-1,4-phenylenediamine was used as the tyrosyl radical trapping agent and used in a radical addition to afford selective modification of the target protein.

Original language	English
Pages (from-to)	8681-8684
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	33
DOIs	https://doi.org/10.1002/anie.201303831
Publication status	Published - 2013 Aug 12

Keywords

photocatalysts
protein modifications
radical reactions
single-electron transfer
tyrosine

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10.1002/anie.201303831

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abstract = "A photocatalyst ([Ru(bpy)3]2+) bound to a protein ligand was essential for the title method. Local single-electron transfer from the catalyst resulted in the formation of tyrosyl radicals. N′-Acetyl-N,N- dimethyl-1,4-phenylenediamine was used as the tyrosyl radical trapping agent and used in a radical addition to afford selective modification of the target protein.",

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KW - radical reactions

KW - single-electron transfer

KW - tyrosine

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Ligand-directed selective protein modification based on local single-electron-transfer catalysis

Abstract

Keywords

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