TY - JOUR
T1 - Ligand-induced structural changes in a membrane-reconstituted ion channel observed with atomic force microscopy
AU - Shinozaki, Youichi
AU - Tanaka, Aya
AU - Kasai, Nahoko
AU - Torimitsu, Keiichi
AU - Sumitomo, Koji
PY - 2014/2
Y1 - 2014/2
N2 - We investigated structural changes in ligand-gated ion channel proteins reconstituted into supported lipid bilayers. The ion channels' extracellular parts were highly dynamic and exhibited agonist-induced changes, which were inhibited by antagonists. Our data demonstrate that, by using small exogenously applied compounds (i.e., ligands), ion channel proteins reconstituted into supported lipid bilayers on a substrate can be controlled.
AB - We investigated structural changes in ligand-gated ion channel proteins reconstituted into supported lipid bilayers. The ion channels' extracellular parts were highly dynamic and exhibited agonist-induced changes, which were inhibited by antagonists. Our data demonstrate that, by using small exogenously applied compounds (i.e., ligands), ion channel proteins reconstituted into supported lipid bilayers on a substrate can be controlled.
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UR - http://www.scopus.com/inward/citedby.url?scp=84893317349&partnerID=8YFLogxK
U2 - 10.7567/APEX.7.027001
DO - 10.7567/APEX.7.027001
M3 - Article
AN - SCOPUS:84893317349
SN - 1882-0778
VL - 7
JO - Applied Physics Express
JF - Applied Physics Express
IS - 2
M1 - 027001
ER -