Light-addressable potentiometric sensor as a sensing element in plug-based microfluidic devices

Ko Ichiro Miyamoto; Takuya Sato; Minami Abe; Torsten Wagner; Michael J. Schöning; Tatsuo Yoshinobu

doi:10.3390/mi7070111

Light-addressable potentiometric sensor as a sensing element in plug-based microfluidic devices

Ko Ichiro Miyamoto, Takuya Sato, Minami Abe, Torsten Wagner, Michael J. Schöning, Tatsuo Yoshinobu

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement.

Original language	English
Article number	111
Journal	Micromachines
Volume	7
Issue number	7
DOIs	https://doi.org/10.3390/mi7070111
Publication status	Published - 2016 Jul 1

Keywords

Chemical sensor
Light-addressable potentiometric sensor
Plug-based microfluidic device

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10.3390/mi7070111

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abstract = "A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement.",

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author = "Miyamoto, {Ko Ichiro} and Takuya Sato and Minami Abe and Torsten Wagner and Sch{\"o}ning, {Michael J.} and Tatsuo Yoshinobu",

note = "Funding Information: This work was supported by JSPS Grant-in-Aid for Scientific Research (B) (contract No. 24310098). A part of this research was carried out at the Machine Shop Division of Fundamental Technology Center, Research Institute of Electrical Communication, Tohoku University. Publisher Copyright: {\textcopyright} 2016 by the authors; licensee MDPI, Basel, Switzerland.",

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doi = "10.3390/mi7070111",

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AU - Wagner, Torsten

AU - Schöning, Michael J.

AU - Yoshinobu, Tatsuo

N1 - Funding Information: This work was supported by JSPS Grant-in-Aid for Scientific Research (B) (contract No. 24310098). A part of this research was carried out at the Machine Shop Division of Fundamental Technology Center, Research Institute of Electrical Communication, Tohoku University. Publisher Copyright: © 2016 by the authors; licensee MDPI, Basel, Switzerland.

PY - 2016/7/1

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N2 - A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement.

AB - A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement.

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Light-addressable potentiometric sensor as a sensing element in plug-based microfluidic devices

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