Limb salvage surgery has a higher complication rate than amputation but is still beneficial for patients younger than 10 years old with osteosarcoma of an extremity

Yoichi Kaneuchi, Shinichirou Yoshida, Tomohiro Fujiwara, Scott Evans, Adesegun Abudu

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Background/Purpose: Limb preserving surgery for the treatment of patients with osteosarcoma younger than 10 years old is challenging and some authors have advocated amputation to reduce the risk of complications. The aim of this study was to compare the clinical outcomes and surgical complications of patients with osteosarcoma of the extremity aged <10 years old who were treated with limb salvage and amputation. Patients and methods: Retrospective review of patients aged <10 years old who were treated for primary osteosarcoma of bone between 2000 and 2018. Results: We analyzed 82 consecutive patients (32 males, 50 females; median age 8, range 3–9 yrs). Limb-salvage surgery (LSS; n = 65, 79%) and amputation (n = 17, 21%) were performed. Fourteen patients had metastasis at surgery. In patients without metastasis at surgery, the metastasis-free and overall survival rates at 5 years following LSS vs. amputation were 75% vs. 58% (p = 0.162) and 71% vs. 55% (p = 0.516), respectively. The 2-year and 5-year OS rates of the LSS and amputation groups of patients with metastasis at surgery were 88% versus 83% and 50% versus 0%, respectively (p = 0.180). The overall complication rates were 46% post-LSS with 31% requiring re-operation versus 12% post-amputation, with 6% requiring re-operation (p = 0.010). Conclusion: The prognosis of patients with localized osteosarcoma aged <10 years undergoing LSS is similar to those treated with amputation, but LSS is associated with a higher risk of complications and subsequent re-operation.

Original languageEnglish
Pages (from-to)702-709
Number of pages8
JournalJournal of Pediatric Surgery
Volume57
Issue number11
DOIs
Publication statusPublished - 2022 Nov

Keywords

  • Amputation
  • Limb salvage surgery
  • Osteosarcoma
  • Pediatric
  • Surgical complication
  • Survival

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