TY - JOUR
T1 - Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice
AU - Nakasone, Chikara
AU - Kawakami, Kazuyoshi
AU - Hoshino, Tomoaki
AU - Kawase, Yusuke
AU - Yokota, Koichi
AU - Yoshino, Kohichiro
AU - Takeda, Kiyoshi
AU - Akira, Shizuo
AU - Saito, Atsushi
PY - 2004/10
Y1 - 2004/10
N2 - We report that clearance of Pseudomonas aeruginosa, accumulation of neutrophils, and synthesis of tumor necrosis factor alpha and macrophage inflammatory protein 2 in the infected lung were not largely different in interleukin-18 (IL-18) knockout or transgenic mice compared with control mice. Our results suggest a limited role for IL-18 in the host defense against P. aeruginosa.
AB - We report that clearance of Pseudomonas aeruginosa, accumulation of neutrophils, and synthesis of tumor necrosis factor alpha and macrophage inflammatory protein 2 in the infected lung were not largely different in interleukin-18 (IL-18) knockout or transgenic mice compared with control mice. Our results suggest a limited role for IL-18 in the host defense against P. aeruginosa.
UR - http://www.scopus.com/inward/record.url?scp=4644243186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4644243186&partnerID=8YFLogxK
U2 - 10.1128/IAI.72.10.6176-6180.2003
DO - 10.1128/IAI.72.10.6176-6180.2003
M3 - Article
C2 - 15385528
AN - SCOPUS:4644243186
SN - 0019-9567
VL - 72
SP - 6176
EP - 6180
JO - Infection and Immunity
JF - Infection and Immunity
IS - 10
ER -
