Linkage and association of childhood asthma with the chromosome 12 genes

Chenchen Shao, Yoichi Suzuki, Fumiaki Kamada, Kiyoshi Kanno, Mayumi Tamari, Koichi Hasegawa, Yoko Aoki, Shigeo Kure, Xue Yang, Hiroko Endo, Reiko Takayanagi, Chifuyu Nakazawa, Toshio Morikawa, Miki Morikawa, Shigeaki Miyabayashi, Yasushi Chiba, Minoru Karahashi, Seichi Saito, Gen Tamura, Taro ShirakawaYoichi Matsubara

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48 Citations (Scopus)


Several studies have shown linkage of chromosome region 12q13-24 to bronchial asthma and related phenotypes in ethnically diverse populations. In the Japanese population, a genome-wide study failed to show strong evidence of linkage of this region. Chromosome 12 genes that showed association with the disease in at least one report include: the signal transducer and activator of transcription 6 gene (STAT6), the nitrogen oxide synthetase 1 gene (NOS1), the interferon γ gene (IFNG), and the activation-induced cytidine deaminase gene (AICDA). To evaluate the linkage between chromosome 12 and childhood asthma in the Japanese population, we performed sib-pair linkage analysis on childhood asthma families using 18 microsatellite markers on chromosome 12. To investigate association between chromosome 12 candidate genes and asthma, distributions of alleles and genotypes of repeat polymorphisms of STAT6, NOS1, and IFNG were compared between controls and patients. Single nucleotide polymorphism of AICDA was also investigated. Chromosome region 12q24.23-q24.33 showed suggestive linkage to asthma. The NOS1 intron 2 GT repeat and STAT6 exon 1 GT repeat were associated with asthma. Neither the IFNG intron 1 CA repeat nor 465C/T of AICDA showed any association with asthma. Our results suggest that NOS1 and STAT6 are asthma-susceptibility genes and that chromosome region 12q24.23-q24.33 contains other susceptibility gene(s).

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalJournal of Human Genetics
Issue number3
Publication statusPublished - 2004


  • Association
  • Childhood asthma
  • Linkage
  • NOS1
  • Polymorphism
  • STAT6


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