Lipoprotein Glomerulopathy: Glomerular Lipoprotein Thrombi in a Patient With Hyperlipoproteinemia

Takao Saito; Hiroshi Sato; Ken ichi Kudo; Sin ichi Oikawa; Toshikatsu Shibata; Yoshihito Hara; Kaoru Yoshinaga; Hiroshi Sakaguchi

doi:10.1016/S0272-6386(89)80134-9

Lipoprotein Glomerulopathy: Glomerular Lipoprotein Thrombi in a Patient With Hyperlipoproteinemia

Takao Saito, Hiroshi Sato, Ken ichi Kudo, Sin ichi Oikawa, Toshikatsu Shibata, Yoshihito Hara, Kaoru Yoshinaga, Hiroshi Sakaguchi

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

An unusual nephropathy presumably induced by abnormal lipid metabolism is described in a 57-year-old woman who presented with proteinuria and edema. Histology at renal biopsy was characterized by marked dilatation of capillary lumina. Sudan staining and electron microscopy demonstrated lipid droplets occupying the capillary lumina. The patient had no particular clinical symptoms of lipidosis, but hyperlipoproteinemia similar to type III was suggested by lipid profiles. The nephropathy is thought to be an inherited disorder because proteinuria was detected in her sisters and similar renal histology and lipid profile were observed in one of her sisters. This is believed to be the first detailed report of glomerular lipoprotein thrombi.

Original language	English
Pages (from-to)	148-153
Number of pages	6
Journal	American Journal of Kidney Diseases
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/S0272-6386(89)80134-9
Publication status	Published - 1989
Externally published	Yes

Keywords

Lipoprotein glomerulopathy
apolipoprotein E
glomerular lipoprotein thrombi
proteinuria
type III hyperlipoproteinemia

ASJC Scopus subject areas

Nephrology

Access to Document

10.1016/S0272-6386(89)80134-9

Cite this

@article{8d325a19e26541fca348a9f52adbff4b,

title = "Lipoprotein Glomerulopathy: Glomerular Lipoprotein Thrombi in a Patient With Hyperlipoproteinemia",

abstract = "An unusual nephropathy presumably induced by abnormal lipid metabolism is described in a 57-year-old woman who presented with proteinuria and edema. Histology at renal biopsy was characterized by marked dilatation of capillary lumina. Sudan staining and electron microscopy demonstrated lipid droplets occupying the capillary lumina. The patient had no particular clinical symptoms of lipidosis, but hyperlipoproteinemia similar to type III was suggested by lipid profiles. The nephropathy is thought to be an inherited disorder because proteinuria was detected in her sisters and similar renal histology and lipid profile were observed in one of her sisters. This is believed to be the first detailed report of glomerular lipoprotein thrombi.",

keywords = "Lipoprotein glomerulopathy, apolipoprotein E, glomerular lipoprotein thrombi, proteinuria, type III hyperlipoproteinemia",

author = "Takao Saito and Hiroshi Sato and Kudo, {Ken ichi} and Oikawa, {Sin ichi} and Toshikatsu Shibata and Yoshihito Hara and Kaoru Yoshinaga and Hiroshi Sakaguchi",

year = "1989",

doi = "10.1016/S0272-6386(89)80134-9",

language = "English",

volume = "13",

pages = "148--153",

journal = "American Journal of Kidney Diseases",

issn = "0272-6386",

publisher = "W.B. Saunders Ltd",

number = "2",

}

TY - JOUR

T1 - Lipoprotein Glomerulopathy

T2 - Glomerular Lipoprotein Thrombi in a Patient With Hyperlipoproteinemia

AU - Saito, Takao

AU - Sato, Hiroshi

AU - Kudo, Ken ichi

AU - Oikawa, Sin ichi

AU - Shibata, Toshikatsu

AU - Hara, Yoshihito

AU - Yoshinaga, Kaoru

AU - Sakaguchi, Hiroshi

PY - 1989

Y1 - 1989

N2 - An unusual nephropathy presumably induced by abnormal lipid metabolism is described in a 57-year-old woman who presented with proteinuria and edema. Histology at renal biopsy was characterized by marked dilatation of capillary lumina. Sudan staining and electron microscopy demonstrated lipid droplets occupying the capillary lumina. The patient had no particular clinical symptoms of lipidosis, but hyperlipoproteinemia similar to type III was suggested by lipid profiles. The nephropathy is thought to be an inherited disorder because proteinuria was detected in her sisters and similar renal histology and lipid profile were observed in one of her sisters. This is believed to be the first detailed report of glomerular lipoprotein thrombi.

AB - An unusual nephropathy presumably induced by abnormal lipid metabolism is described in a 57-year-old woman who presented with proteinuria and edema. Histology at renal biopsy was characterized by marked dilatation of capillary lumina. Sudan staining and electron microscopy demonstrated lipid droplets occupying the capillary lumina. The patient had no particular clinical symptoms of lipidosis, but hyperlipoproteinemia similar to type III was suggested by lipid profiles. The nephropathy is thought to be an inherited disorder because proteinuria was detected in her sisters and similar renal histology and lipid profile were observed in one of her sisters. This is believed to be the first detailed report of glomerular lipoprotein thrombi.

KW - Lipoprotein glomerulopathy

KW - apolipoprotein E

KW - glomerular lipoprotein thrombi

KW - proteinuria

KW - type III hyperlipoproteinemia

UR - http://www.scopus.com/inward/record.url?scp=0024551515&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024551515&partnerID=8YFLogxK

U2 - 10.1016/S0272-6386(89)80134-9

DO - 10.1016/S0272-6386(89)80134-9

M3 - Article

C2 - 2644825

AN - SCOPUS:0024551515

SN - 0272-6386

VL - 13

SP - 148

EP - 153

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

IS - 2

ER -

Lipoprotein Glomerulopathy: Glomerular Lipoprotein Thrombi in a Patient With Hyperlipoproteinemia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this