Liver targeting of plasmid DNA with a cationized pullulan for tumor suppression

M. Yamamoto, J. Jo, K. Matsumoto, T. Nakamura, Y. Tabata

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


The preparation of a non-viral gene carrier to specifically enhance the gene expression of plasmid DNA of NK4 in the liver was discussed. An experimental mouse model of liver metastasis was prepared by intravenous injection of RLmale 1 lymphoma cells. The mouse survival and serum glutamic pyruvic transaminase (GPT) activity were examined at different time intervals. It was observed that when the in vitro gene expression was examined in the presence of asialofetuin, the expression level was suppressed for all the complexes. It was also observed that the survival of mouse bearing RL male 1 cells was prolonged only by injection of NK4 plasmid DNA complex with spermine-pullulan.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
Publication statusPublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 2004 May 172004 May 21

Publication series

NameTransactions - 7th World Biomaterials Congress


ConferenceTransactions - 7th World Biomaterials Congress


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