TY - JOUR
T1 - Localization of transforming growth factor-β Type I and Type II receptors in mouse development
AU - Iseki, Sachiko
AU - Osumi-Yamashita, Noriko
AU - Miyazono, Kohei
AU - Franzén, Petra
AU - Ichijo, Hidenori
AU - Ohtani, Haruo
AU - Hayashi, Yoshio
AU - Eto, Kazuhiro
PY - 1995/8
Y1 - 1995/8
N2 - We have investigated the localization pattern of the transforming growth factor-β (TGF-β) receptors type I (TβR-I) and type II (TβR-II) during mouse organogenesis by immunohistochemical analysis. Staining of both receptors was found in many developing organs, e.g., bone, teeth, Meckel's cartilage, and neural tissues, where the expression of their ligands has been previously reported. During the investigated stages, expression of TβR-I was more ubiquitous than that of TβR-II. TβR-II preferentially localized in the undifferentiated mesenchymal cells which subsequently differentiated into bone. There was no staining of TβR-II in the central nervous system, while intense TβR-I staining was found specifically in nervous tissues. Expression of TβR-I and TβR-II was mostly coincident with that of their ligands, suggesting that TGF-βs act as multiple mediators during organogenesis. In addition, colocalization of both receptors in the epithelia of the tooth bud and submandibular gland, which were actively invaginating into the mesenchyme, leads us to speculate that both receptors may be necessary for dynamic epithelial morphogenesis.
AB - We have investigated the localization pattern of the transforming growth factor-β (TGF-β) receptors type I (TβR-I) and type II (TβR-II) during mouse organogenesis by immunohistochemical analysis. Staining of both receptors was found in many developing organs, e.g., bone, teeth, Meckel's cartilage, and neural tissues, where the expression of their ligands has been previously reported. During the investigated stages, expression of TβR-I was more ubiquitous than that of TβR-II. TβR-II preferentially localized in the undifferentiated mesenchymal cells which subsequently differentiated into bone. There was no staining of TβR-II in the central nervous system, while intense TβR-I staining was found specifically in nervous tissues. Expression of TβR-I and TβR-II was mostly coincident with that of their ligands, suggesting that TGF-βs act as multiple mediators during organogenesis. In addition, colocalization of both receptors in the epithelia of the tooth bud and submandibular gland, which were actively invaginating into the mesenchyme, leads us to speculate that both receptors may be necessary for dynamic epithelial morphogenesis.
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U2 - 10.1006/excr.1995.1237
DO - 10.1006/excr.1995.1237
M3 - Article
C2 - 7641785
AN - SCOPUS:0029150902
SN - 0014-4827
VL - 219
SP - 339
EP - 347
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 2
ER -