LOH analyses of premalignant and malignant lesions of human breast: frequent LOH in 8p, 16q, and 17q in atypical ductal hyperplasia.

M. Amari; A. Suzuki; T. Moriya; K. Yoshinaga; G. Amano; H. Sasano; N. Ohuchi; S. Satomi; A. Horii

doi:10.3892/or.6.6.1277

LOH analyses of premalignant and malignant lesions of human breast: frequent LOH in 8p, 16q, and 17q in atypical ductal hyperplasia.

M. Amari, A. Suzuki, T. Moriya, K. Yoshinaga, G. Amano, H. Sasano, N. Ohuchi, S. Satomi, A. Horii

Research output: Contribution to journal › Article › peer-review

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Abstract

The number of breast cancer patients is increasing yearly, and it is important to establish effective methods for clinical management. We investigated loss of heterozygosity (LOH) in tumors derived from 23 patients that harbored synchronous lesions of atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC). Fourteen selected microsatellite markers that were mapped to and/or very close to the tumor suppressor genes or regions with frequent LOH in breast cancer. Our results suggested that i) losses of chromosomal regions 8p, 16q, and 17q are early genetic changes, and ii) ADH is a premalignant lesion for the development of breast cancer.

Original language	English
Pages (from-to)	1277-1280
Number of pages	4
Journal	Oncology reports
Volume	6
Issue number	6
DOIs	https://doi.org/10.3892/or.6.6.1277
Publication status	Published - 1999

ASJC Scopus subject areas

Oncology
Cancer Research

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abstract = "The number of breast cancer patients is increasing yearly, and it is important to establish effective methods for clinical management. We investigated loss of heterozygosity (LOH) in tumors derived from 23 patients that harbored synchronous lesions of atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC). Fourteen selected microsatellite markers that were mapped to and/or very close to the tumor suppressor genes or regions with frequent LOH in breast cancer. Our results suggested that i) losses of chromosomal regions 8p, 16q, and 17q are early genetic changes, and ii) ADH is a premalignant lesion for the development of breast cancer.",

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T1 - LOH analyses of premalignant and malignant lesions of human breast

T2 - frequent LOH in 8p, 16q, and 17q in atypical ductal hyperplasia.

AU - Amari, M.

AU - Suzuki, A.

AU - Moriya, T.

AU - Yoshinaga, K.

AU - Amano, G.

AU - Sasano, H.

AU - Ohuchi, N.

AU - Satomi, S.

AU - Horii, A.

PY - 1999

Y1 - 1999

N2 - The number of breast cancer patients is increasing yearly, and it is important to establish effective methods for clinical management. We investigated loss of heterozygosity (LOH) in tumors derived from 23 patients that harbored synchronous lesions of atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC). Fourteen selected microsatellite markers that were mapped to and/or very close to the tumor suppressor genes or regions with frequent LOH in breast cancer. Our results suggested that i) losses of chromosomal regions 8p, 16q, and 17q are early genetic changes, and ii) ADH is a premalignant lesion for the development of breast cancer.

AB - The number of breast cancer patients is increasing yearly, and it is important to establish effective methods for clinical management. We investigated loss of heterozygosity (LOH) in tumors derived from 23 patients that harbored synchronous lesions of atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC). Fourteen selected microsatellite markers that were mapped to and/or very close to the tumor suppressor genes or regions with frequent LOH in breast cancer. Our results suggested that i) losses of chromosomal regions 8p, 16q, and 17q are early genetic changes, and ii) ADH is a premalignant lesion for the development of breast cancer.

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LOH analyses of premalignant and malignant lesions of human breast: frequent LOH in 8p, 16q, and 17q in atypical ductal hyperplasia.

Abstract

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UN SDGs

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