Low-energy extracorporeal shock wave ameliorates ischemic acute kidney injury in rats

Mai Yoshida, Takashi Nakamichi, Takefumi Mori, Kenta Ito, Hiroaki Shimokawa, Sadayoshi Ito

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Background: Low-energy extracorporeal shock wave (SW) improves ventricular function in ischemic cardiomyopathy through the upregulation of vascular endothelial growth factor (VEGF). VEGF is known to play important roles in acute kidney injury (AKI), and the present study investigates the efficacy of SW for AKI by renal ischemia–reperfusion (I/R) injury. Methods: Male 8-week-old Sprague–Dawley rats were divided into the following groups: SW-treated I/R group (I/R-SW), untreated I/R group (I/R), and Sham group. To induce I/R, the left renal pedicles were clamped for 45 min. The I/R-SW group was treated with SW to both kidneys on the immediate postoperative period (day 0), days 1, 2, 7, 8, 9, 14, 15, and 16. Rats were killed on day 2 and day 20 to determine histology, renal function, and Vegf family mRNA expression. Results: Plasma creatinine on day 2 was significantly lower in the I/R-SW group than in the I/R group. Light microscopy revealed significantly lower tubular injury scores for the outer medulla in the I/R-SW group than in the I/R group. Podoplanin-positive lymphatic vessels were significantly increased in the left (affected side) outer medulla in the I/R-SW group on day 20. The expression levels of Vegf in the right (intact side) cortex were significantly higher in the I/R-SW group than in the I/R group on day 2. Conclusion: Shock wave ameliorated renal tubular injury and renal function in AKI model, through the stimulation of Vegf family expression and lymphangiogenesis. SW may be effective as a non-invasive treatment for ischemic AKI.

Original languageEnglish
Pages (from-to)597-605
Number of pages9
JournalClinical and experimental nephrology
Issue number5
Publication statusPublished - 2019 May 1


  • Ischemic acute kidney injury
  • Lymphangiogenesis
  • Shock wave
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)


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