Low Incidence of a Nucleotide Sequence Alteration of the Neurofibromatosis 2 Gene in Human Breast Cancers

Sadanori Yaegashi; Richard Sachse; Noriaki Ohuchi; Shozo Mori; Takao Sekiya

doi:10.1111/j.1349-7006.1995.tb03003.x

Low Incidence of a Nucleotide Sequence Alteration of the Neurofibromatosis 2 Gene in Human Breast Cancers

Sadanori Yaegashi, Richard Sachse, Noriaki Ohuchi, Shozo Mori, Takao Sekiya

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single‐strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor‐specific single‐base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.

Original language	English
Pages (from-to)	929-933
Number of pages	5
Journal	Japanese Journal of Cancer Research
Volume	86
Issue number	10
DOIs	https://doi.org/10.1111/j.1349-7006.1995.tb03003.x
Publication status	Published - 1995 Oct
Externally published	Yes

Keywords

Human breast cancer
Mutation
NF2gene
Polymorphism
SSCP analysis

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.1995.tb03003.x

Cite this

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title = "Low Incidence of a Nucleotide Sequence Alteration of the Neurofibromatosis 2 Gene in Human Breast Cancers",

abstract = "We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single‐strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor‐specific single‐base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.",

keywords = "Human breast cancer, Mutation, NF2gene, Polymorphism, SSCP analysis",

author = "Sadanori Yaegashi and Richard Sachse and Noriaki Ohuchi and Shozo Mori and Takao Sekiya",

year = "1995",

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doi = "10.1111/j.1349-7006.1995.tb03003.x",

language = "English",

volume = "86",

pages = "929--933",

journal = "Cancer Science",

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T1 - Low Incidence of a Nucleotide Sequence Alteration of the Neurofibromatosis 2 Gene in Human Breast Cancers

AU - Yaegashi, Sadanori

AU - Sachse, Richard

AU - Ohuchi, Noriaki

AU - Mori, Shozo

AU - Sekiya, Takao

PY - 1995/10

Y1 - 1995/10

N2 - We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single‐strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor‐specific single‐base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.

AB - We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single‐strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor‐specific single‐base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.

KW - Human breast cancer

KW - Mutation

KW - NF2gene

KW - Polymorphism

KW - SSCP analysis

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DO - 10.1111/j.1349-7006.1995.tb03003.x

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SN - 1347-9032

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EP - 933

JO - Cancer Science

JF - Cancer Science

IS - 10

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Low Incidence of a Nucleotide Sequence Alteration of the Neurofibromatosis 2 Gene in Human Breast Cancers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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