We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single‐strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor‐specific single‐base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.
|Number of pages||5|
|Journal||Japanese Journal of Cancer Research|
|Publication status||Published - 1995 Oct|
- Human breast cancer
- SSCP analysis
ASJC Scopus subject areas
- Cancer Research