Lupinacidin C, an inhibitor of tumor cell invasion from micromonospora lupini

Yasuhiro Igarashi; Saeko Yanase; Kohei Sugimoto; Masaru Enomoto; Satoshi Miyanaga; Martha E. Trujillo; Ikuo Saiki; Shigefumi Kuwahara

doi:10.1021/np100779t

Lupinacidin C, an inhibitor of tumor cell invasion from micromonospora lupini

Yasuhiro Igarashi, Saeko Yanase, Kohei Sugimoto, Masaru Enomoto, Satoshi Miyanaga, Martha E. Trujillo, Ikuo Saiki, Shigefumi Kuwahara

AGR - Agricultural Chemistry

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

A new anthraquinone derivative, lupinacidin C (1), was isolated from the endophytic actinomycete Micromonospora lupini. The structure was elucidated on the basis of spectroscopic analyses, and the absolute configuration was determined by total synthesis. Lupinacidin C (1) exhibited the most potent inhibitory effects among the congeners on the invasion of murine colon carcinoma cells into the reconstituted basement membrane.

Original language	English
Pages (from-to)	862-865
Number of pages	4
Journal	Journal of Natural Products
Volume	74
Issue number	4
DOIs	https://doi.org/10.1021/np100779t
Publication status	Published - 2011 Apr 25

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10.1021/np100779t

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abstract = "A new anthraquinone derivative, lupinacidin C (1), was isolated from the endophytic actinomycete Micromonospora lupini. The structure was elucidated on the basis of spectroscopic analyses, and the absolute configuration was determined by total synthesis. Lupinacidin C (1) exhibited the most potent inhibitory effects among the congeners on the invasion of murine colon carcinoma cells into the reconstituted basement membrane.",

author = "Yasuhiro Igarashi and Saeko Yanase and Kohei Sugimoto and Masaru Enomoto and Satoshi Miyanaga and Trujillo, {Martha E.} and Ikuo Saiki and Shigefumi Kuwahara",

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AU - Igarashi, Yasuhiro

AU - Yanase, Saeko

AU - Sugimoto, Kohei

AU - Enomoto, Masaru

AU - Miyanaga, Satoshi

AU - Trujillo, Martha E.

AU - Saiki, Ikuo

AU - Kuwahara, Shigefumi

PY - 2011/4/25

Y1 - 2011/4/25

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AB - A new anthraquinone derivative, lupinacidin C (1), was isolated from the endophytic actinomycete Micromonospora lupini. The structure was elucidated on the basis of spectroscopic analyses, and the absolute configuration was determined by total synthesis. Lupinacidin C (1) exhibited the most potent inhibitory effects among the congeners on the invasion of murine colon carcinoma cells into the reconstituted basement membrane.

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Lupinacidin C, an inhibitor of tumor cell invasion from micromonospora lupini

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