Lysosome-Related Organelles

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5 Citations (Scopus)


Lysosome-related organelles (LROs) are a group of cell-type-specific membrane compartments in metazoans that share several features, including low pH and certain luminal contents, with lysosomes. Despite sharing features with lysosomes, the LROs of higher animals are highly specialized in terms of their morphology and composition, and they perform specialized functions, including pigmentation, hemostasis, immunity, and lung plasticity. Because of their importance in biological activities, defects in the biogenesis and/or transport of LROs are known to cause human genetic diseases, including Griscelli syndrome (GS) and Hermansky-Pudlak syndrome (HPS), which are characterized by hypopigmentation of hair and skin, delayed blood clotting, immunodeficiency, and/or pulmonary fibrosis.

Original languageEnglish
Title of host publicationOrganizational Cell Biology
PublisherElsevier Inc.
Number of pages8
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
Publication statusPublished - 2016


  • BLOC complex
  • Chédiak-Higashi syndrome
  • Dense granule
  • Griscelli syndrome
  • Hermansky-Pudlak syndrome
  • Lamellar body
  • Lysosome-related organelle
  • Lytic granule
  • MHC class II compartment
  • Melanosome
  • Membrane traffic
  • Secretory lysosome
  • Small GTPase Rab
  • Weibel-Palade body
  • α Granule


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