M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site

Yota Sato; Taku Fujimura; Sadanori Furudate; Aya Kakizaki; Osamu Iizawa; Setsuya Aiba

doi:10.1159/000447709

M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site

Yota Sato, Taku Fujimura, Sadanori Furudate, Aya Kakizaki, Osamu Iizawa, Setsuya Aiba

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Since bacillus Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis, lupus vulgaris (LV) is reported as one of the rare complications after BCG vaccination, correlating with immunosuppression in the lesional skin. In this report, we describe a case of LV arising from the BCG vaccination site 22 years after vaccination. Interestingly, in the present case, granuloma cells were composed of M2-polarized macrophages. Our case might explain the contribution of M2-polarized macrophages to the biology of LV arising from a BCG vaccination site.

Original language	English
Pages (from-to)	202-206
Number of pages	5
Journal	Case Reports in Dermatology
Volume	8
Issue number	2
DOIs	https://doi.org/10.1159/000447709
Publication status	Published - 2016

Keywords

Bacillus Calmette-Guérin
Immunosuppression
Lupus vulgaris
M2-polarized macrophages

ASJC Scopus subject areas

Dermatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000447709

Cite this

@article{1daf8b0197764354827137daa91fee19,

title = "M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Gu{\'e}rin Vaccination Site",

abstract = "Since bacillus Calmette-Gu{\'e}rin (BCG) is an attenuated strain of Mycobacterium bovis, lupus vulgaris (LV) is reported as one of the rare complications after BCG vaccination, correlating with immunosuppression in the lesional skin. In this report, we describe a case of LV arising from the BCG vaccination site 22 years after vaccination. Interestingly, in the present case, granuloma cells were composed of M2-polarized macrophages. Our case might explain the contribution of M2-polarized macrophages to the biology of LV arising from a BCG vaccination site.",

keywords = "Bacillus Calmette-Gu{\'e}rin, Immunosuppression, Lupus vulgaris, M2-polarized macrophages",

author = "Yota Sato and Taku Fujimura and Sadanori Furudate and Aya Kakizaki and Osamu Iizawa and Setsuya Aiba",

note = "Publisher Copyright: {\textcopyright} 2016 The Author(s). Published by S. Karger AG, Basel.",

year = "2016",

doi = "10.1159/000447709",

language = "English",

volume = "8",

pages = "202--206",

journal = "Case Reports in Dermatology",

issn = "1662-6567",

publisher = "S. Karger AG",

number = "2",

}

TY - JOUR

T1 - M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site

AU - Sato, Yota

AU - Fujimura, Taku

AU - Furudate, Sadanori

AU - Kakizaki, Aya

AU - Iizawa, Osamu

AU - Aiba, Setsuya

PY - 2016

Y1 - 2016

N2 - Since bacillus Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis, lupus vulgaris (LV) is reported as one of the rare complications after BCG vaccination, correlating with immunosuppression in the lesional skin. In this report, we describe a case of LV arising from the BCG vaccination site 22 years after vaccination. Interestingly, in the present case, granuloma cells were composed of M2-polarized macrophages. Our case might explain the contribution of M2-polarized macrophages to the biology of LV arising from a BCG vaccination site.

AB - Since bacillus Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis, lupus vulgaris (LV) is reported as one of the rare complications after BCG vaccination, correlating with immunosuppression in the lesional skin. In this report, we describe a case of LV arising from the BCG vaccination site 22 years after vaccination. Interestingly, in the present case, granuloma cells were composed of M2-polarized macrophages. Our case might explain the contribution of M2-polarized macrophages to the biology of LV arising from a BCG vaccination site.

KW - Bacillus Calmette-Guérin

KW - Immunosuppression

KW - Lupus vulgaris

KW - M2-polarized macrophages

UR - http://www.scopus.com/inward/record.url?scp=84979030674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979030674&partnerID=8YFLogxK

U2 - 10.1159/000447709

DO - 10.1159/000447709

M3 - Article

AN - SCOPUS:84979030674

SN - 1662-6567

VL - 8

SP - 202

EP - 206

JO - Case Reports in Dermatology

JF - Case Reports in Dermatology

IS - 2

ER -

M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this