TY - JOUR
T1 - Macrophage phagocytosis of biomedical Mg alloy degradation products prepared by electrochemical method
AU - Zhang, Jian
AU - Hiromoto, Sachiko
AU - Yamazaki, Tomohiko
AU - Huang, Hua
AU - Jia, Gaozhi
AU - Li, Haiyan
AU - Yuan, Guangyin
N1 - Funding Information:
Jian Zhang would like to thank Chinese Scholarship Council (CSC) for financial support. The authors acknowledge the financial support from WPI-MANA, Japan's Ministry of Education, Culture, Sports, Science and Technology (MEXT), the National High Technology Research and Development Program of China (863 Program, No. 2015AA033603), the National Natural Science Foundation of China (No. 51571143) and the Science and Technology Commission of Shanghai Municipality (No. 14DZ1940800). The authors would also greatly acknowledge NIMS Molecule & Material Synthesis Platform for the assistance with the cell experiments.
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Biomedical Mg alloy is promising for its widespread use clinically. In vitro and in vivo studies showed that the degradation products of biomedical Mg alloy were composed of O, P, Ca, Mg and other alloying elements. However, little is known about the metabolism of the degradation products. In this study, the in vitro macrophage phagocytosis of the degradation products of a biomedical Mg-Nd-Zn-Zr alloy was directly observed. This result affirms the necessity to investigate the long-term fate of Mg alloy degradation products in physiological environments. Besides, an electrochemical method was proposed to prepare enough amount of degradation products in vitro efficiently.
AB - Biomedical Mg alloy is promising for its widespread use clinically. In vitro and in vivo studies showed that the degradation products of biomedical Mg alloy were composed of O, P, Ca, Mg and other alloying elements. However, little is known about the metabolism of the degradation products. In this study, the in vitro macrophage phagocytosis of the degradation products of a biomedical Mg-Nd-Zn-Zr alloy was directly observed. This result affirms the necessity to investigate the long-term fate of Mg alloy degradation products in physiological environments. Besides, an electrochemical method was proposed to prepare enough amount of degradation products in vitro efficiently.
KW - Degradation product
KW - In vitro
KW - Macrophage phagocytosis
KW - Magnesium alloy
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U2 - 10.1016/j.msec.2017.02.126
DO - 10.1016/j.msec.2017.02.126
M3 - Article
C2 - 28415404
AN - SCOPUS:85014712277
SN - 0928-4931
VL - 75
SP - 1178
EP - 1183
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -