TY - JOUR
T1 - Magnetic field dependence of heating property of resovist® for magnetic hyperthermia
AU - Tonthat, Loi
AU - Yamamoto, Yoshiyuki
AU - Aki, Fumitaka
AU - Saito, Hajime
AU - Mitobe, Kazutaka
N1 - Publisher Copyright:
© 2018 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
PY - 2019/4
Y1 - 2019/4
N2 - Resovist®, a MRI contrast agent, has been gaining more attention due to its potential as a therapeutic agent in magnetic hyperthermia and a diagnostic agent in magnetic particle imaging. In this study, we examined the dependence of heating property quantified by the specific absorption rate (SAR) by manipulating the applied magnetic field amplitude and frequency (H = 1.8–7.1 kA/m, f = 500 kHz, and H = 4.8 kA/m, f = 200–1000 kHz). The results indicate that the SAR was linearly proportional to amplitude square and frequency. In addition, the heating efficiency (e.g., SAR = 44 W/g at H = 7.1 kA/m, f = 500 kHz) was sufficient to treat the tumor, which suggests the effectiveness of Resovist® for hyperthermia. The results obtained here may enable us to find the optimal conditions of applied magnetic field and the amount of Resovist® required for treatment.
AB - Resovist®, a MRI contrast agent, has been gaining more attention due to its potential as a therapeutic agent in magnetic hyperthermia and a diagnostic agent in magnetic particle imaging. In this study, we examined the dependence of heating property quantified by the specific absorption rate (SAR) by manipulating the applied magnetic field amplitude and frequency (H = 1.8–7.1 kA/m, f = 500 kHz, and H = 4.8 kA/m, f = 200–1000 kHz). The results indicate that the SAR was linearly proportional to amplitude square and frequency. In addition, the heating efficiency (e.g., SAR = 44 W/g at H = 7.1 kA/m, f = 500 kHz) was sufficient to treat the tumor, which suggests the effectiveness of Resovist® for hyperthermia. The results obtained here may enable us to find the optimal conditions of applied magnetic field and the amount of Resovist® required for treatment.
KW - Resovist®
KW - heating property
KW - magnetic hyperthermia
KW - superparamagnetic particles
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U2 - 10.1002/tee.22848
DO - 10.1002/tee.22848
M3 - Letter
AN - SCOPUS:85058062154
SN - 1931-4973
VL - 14
SP - 648
EP - 649
JO - IEEJ Transactions on Electrical and Electronic Engineering
JF - IEEJ Transactions on Electrical and Electronic Engineering
IS - 4
ER -