Magnetic field dependence of heating property of resovist® for magnetic hyperthermia

Loi Tonthat, Yoshiyuki Yamamoto, Fumitaka Aki, Hajime Saito, Kazutaka Mitobe

Research output: Contribution to journalLetterpeer-review

5 Citations (Scopus)


Resovist®, a MRI contrast agent, has been gaining more attention due to its potential as a therapeutic agent in magnetic hyperthermia and a diagnostic agent in magnetic particle imaging. In this study, we examined the dependence of heating property quantified by the specific absorption rate (SAR) by manipulating the applied magnetic field amplitude and frequency (H = 1.8–7.1 kA/m, f = 500 kHz, and H = 4.8 kA/m, f = 200–1000 kHz). The results indicate that the SAR was linearly proportional to amplitude square and frequency. In addition, the heating efficiency (e.g., SAR = 44 W/g at H = 7.1 kA/m, f = 500 kHz) was sufficient to treat the tumor, which suggests the effectiveness of Resovist® for hyperthermia. The results obtained here may enable us to find the optimal conditions of applied magnetic field and the amount of Resovist® required for treatment.

Original languageEnglish
Pages (from-to)648-649
Number of pages2
JournalIEEJ Transactions on Electrical and Electronic Engineering
Issue number4
Publication statusPublished - 2019 Apr


  • Resovist®
  • heating property
  • magnetic hyperthermia
  • superparamagnetic particles


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