TY - JOUR
T1 - Magnetic Relaxation and Modification of Thiol Groups on Co-Mg Ferrite Nanoparticles for Theranostics
AU - Katayanagi, Hikaru
AU - Sakai, Naoki
AU - Hamada, Sota
AU - Usui, Akihito
AU - Aoki, Kota
AU - Kodama, Keita
AU - Nashimoto, Kentaro
AU - Hosokai, Yoshiyuki
AU - Ichiyanagi, Yuko
N1 - Funding Information:
This study was partially supported by the Precursory Research for Embryonic Science and Technology at the Japan Science and Technology Agency (Y.I.), JST-Mirai Program No. JPMJMI17D7 (Y.I.), and Grant-in-Aid for Science Research No. 25286041 (Y.I.). Authors wish to thank to Mr M. Kondo of instrumental analysis center of YNU.
Funding Information:
This study was partially supported by the Precursory Research for Embryonic Science and Technology at the Japan Science and Technology Agency (Y.I.), JST‐Mirai Program No. JPMJMI17D7 (Y.I.), and Grant‐in‐Aid for Science Research No. 25286041 (Y.I.). Authors wish to thank to Mr M. Kondo of instrumental analysis center of YNU.
Publisher Copyright:
© 2022 Wiley-VCH GmbH.
PY - 2022/10
Y1 - 2022/10
N2 - Co1-xMgxFe2O4 (x=0.0, 0.2, 0.4, 0.6, 0.8, 1.0) nanoparticles embedded in amorphous SiO2 with particle sizes of approximately 4.5 nm were prepared using an original wet chemical method. We performed spin-echo magnetic resonance imaging measurements for Co1-xMgxFe2O4 nanoparticles using a 0.3-T MRI system. The particles exhibited a significant T2 shortening effect compared with that of agarose, depending on the composition. All particles exhibited effective relaxivity, R2, and a significant contrast was observed in the phantom image. Furthermore, thiol group was modified to enable particles to bind specifically to maleimide proteins. These particles are expected to be potential theranostic agents.
AB - Co1-xMgxFe2O4 (x=0.0, 0.2, 0.4, 0.6, 0.8, 1.0) nanoparticles embedded in amorphous SiO2 with particle sizes of approximately 4.5 nm were prepared using an original wet chemical method. We performed spin-echo magnetic resonance imaging measurements for Co1-xMgxFe2O4 nanoparticles using a 0.3-T MRI system. The particles exhibited a significant T2 shortening effect compared with that of agarose, depending on the composition. All particles exhibited effective relaxivity, R2, and a significant contrast was observed in the phantom image. Furthermore, thiol group was modified to enable particles to bind specifically to maleimide proteins. These particles are expected to be potential theranostic agents.
KW - ferrite
KW - magnetic nanoparticles
KW - magnetic resonance imaging
KW - relaxation
KW - theranostics
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U2 - 10.1002/cnma.202200014
DO - 10.1002/cnma.202200014
M3 - Article
AN - SCOPUS:85129858340
SN - 2199-692X
VL - 8
JO - ChemNanoMat
JF - ChemNanoMat
IS - 10
M1 - e202200014
ER -
