Magnetic Relaxation and Modification of Thiol Groups on Co-Mg Ferrite Nanoparticles for Theranostics

Hikaru Katayanagi, Naoki Sakai, Sota Hamada, Akihito Usui, Kota Aoki, Keita Kodama, Kentaro Nashimoto, Yoshiyuki Hosokai, Yuko Ichiyanagi

Research output: Contribution to journalArticlepeer-review


Co1-xMgxFe2O4 (x=0.0, 0.2, 0.4, 0.6, 0.8, 1.0) nanoparticles embedded in amorphous SiO2 with particle sizes of approximately 4.5 nm were prepared using an original wet chemical method. We performed spin-echo magnetic resonance imaging measurements for Co1-xMgxFe2O4 nanoparticles using a 0.3-T MRI system. The particles exhibited a significant T2 shortening effect compared with that of agarose, depending on the composition. All particles exhibited effective relaxivity, R2, and a significant contrast was observed in the phantom image. Furthermore, thiol group was modified to enable particles to bind specifically to maleimide proteins. These particles are expected to be potential theranostic agents.

Original languageEnglish
Article numbere202200014
Issue number10
Publication statusPublished - 2022 Oct
Externally publishedYes


  • ferrite
  • magnetic nanoparticles
  • magnetic resonance imaging
  • relaxation
  • theranostics

ASJC Scopus subject areas

  • Biomaterials
  • Renewable Energy, Sustainability and the Environment
  • Energy Engineering and Power Technology
  • Materials Chemistry


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