TY - JOUR
T1 - Magnetic source imaging in non-lesional neocortical epilepsy
T2 - Additional value and comparison with ICEEG
AU - Schneider, Felix
AU - Alexopoulos, Andreas V.
AU - Wang, Zhong
AU - Almubarak, Salah
AU - Kakisaka, Yosuke
AU - Jin, Kazutaka
AU - Nair, Dileep
AU - Mosher, John C.
AU - Najm, Imad M.
AU - Burgess, Richard C.
PY - 2012/6
Y1 - 2012/6
N2 - Objective: To investigate the utility of magnetic source imaging (MSI) for localizing the epileptogenic zone (EZ) and predicting epilepsy surgery outcome in non-lesional neocortical focal epilepsy (NLNE) patients. Methods: Data from 18 consecutive patients with NLNE who underwent presurgical evaluation including intracranial electroencephalography (ICEEG) and MSI were studied. Follow-up after epilepsy surgery was ≥ 24 months. Intracranial electroencephalography and MSI results were classified using a sublobar classification. Results: Sublobar ICEEG focus was completely resected in 15 patients; seizure-free rate was 60%. Eight patients showed sublobar-concordant ICEEG/MSI results and complete resection of both regions; seizure-free rate was 87.5%. Seizure-free rate in cases not matching these criteria was only 30% (p = 0.013). Conclusions: Magnetoencephalography is a useful tool to localize the EZ and determine the site of surgical resection in NLNE patients. When sublobar concordance with ICEEG is observed, MSI increases the predictive value for a seizure-free epilepsy surgery outcome in these patients.
AB - Objective: To investigate the utility of magnetic source imaging (MSI) for localizing the epileptogenic zone (EZ) and predicting epilepsy surgery outcome in non-lesional neocortical focal epilepsy (NLNE) patients. Methods: Data from 18 consecutive patients with NLNE who underwent presurgical evaluation including intracranial electroencephalography (ICEEG) and MSI were studied. Follow-up after epilepsy surgery was ≥ 24 months. Intracranial electroencephalography and MSI results were classified using a sublobar classification. Results: Sublobar ICEEG focus was completely resected in 15 patients; seizure-free rate was 60%. Eight patients showed sublobar-concordant ICEEG/MSI results and complete resection of both regions; seizure-free rate was 87.5%. Seizure-free rate in cases not matching these criteria was only 30% (p = 0.013). Conclusions: Magnetoencephalography is a useful tool to localize the EZ and determine the site of surgical resection in NLNE patients. When sublobar concordance with ICEEG is observed, MSI increases the predictive value for a seizure-free epilepsy surgery outcome in these patients.
KW - Epilepsy surgery outcome
KW - Intracranial electroencephalography
KW - Magnetic source imaging
KW - Non-lesional neocortical epilepsy
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U2 - 10.1016/j.yebeh.2012.03.029
DO - 10.1016/j.yebeh.2012.03.029
M3 - Article
C2 - 22542998
AN - SCOPUS:84861344049
SN - 1525-5050
VL - 24
SP - 234
EP - 240
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
IS - 2
ER -