Magnetic source imaging in non-lesional neocortical epilepsy: Additional value and comparison with ICEEG

Felix Schneider, Andreas V. Alexopoulos, Zhong Wang, Salah Almubarak, Yosuke Kakisaka, Kazutaka Jin, Dileep Nair, John C. Mosher, Imad M. Najm, Richard C. Burgess

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Objective: To investigate the utility of magnetic source imaging (MSI) for localizing the epileptogenic zone (EZ) and predicting epilepsy surgery outcome in non-lesional neocortical focal epilepsy (NLNE) patients. Methods: Data from 18 consecutive patients with NLNE who underwent presurgical evaluation including intracranial electroencephalography (ICEEG) and MSI were studied. Follow-up after epilepsy surgery was ≥ 24 months. Intracranial electroencephalography and MSI results were classified using a sublobar classification. Results: Sublobar ICEEG focus was completely resected in 15 patients; seizure-free rate was 60%. Eight patients showed sublobar-concordant ICEEG/MSI results and complete resection of both regions; seizure-free rate was 87.5%. Seizure-free rate in cases not matching these criteria was only 30% (p = 0.013). Conclusions: Magnetoencephalography is a useful tool to localize the EZ and determine the site of surgical resection in NLNE patients. When sublobar concordance with ICEEG is observed, MSI increases the predictive value for a seizure-free epilepsy surgery outcome in these patients.

Original languageEnglish
Pages (from-to)234-240
Number of pages7
JournalEpilepsy and Behavior
Issue number2
Publication statusPublished - 2012 Jun


  • Epilepsy surgery outcome
  • Intracranial electroencephalography
  • Magnetic source imaging
  • Non-lesional neocortical epilepsy


Dive into the research topics of 'Magnetic source imaging in non-lesional neocortical epilepsy: Additional value and comparison with ICEEG'. Together they form a unique fingerprint.

Cite this