Magnetocardiography Can Predict Clinical Response and Long-Term Prognosis after Cardiac Resynchronization Therapy

Shunsuke Usami, Hiroshi Takaki, Shuji Hashimoto, Yuko Yamada, Hideo Okamura, Takashi Noda, Kazuhiro Satomi, Takeshi Aiba, Wataru Shimizu, Naohiko Aihara, Shiro Kamakura, Masaru Sugimachi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cardiac resynchronization therapy (CRT) is a treatment for heart failure (HF) with electromechanical dyssynchrony. However, there is no available tool to accurately predict the efficacy. We hypothesized that magnetocardiography (MCG) with high spatio-temporal resolution can predict the CRT response. Methods: We analyzed 64-ch MCGs in 25 patients with HF and QRS prolongation on ECG (18 CLBBB, 7 IVCD). According to the 2-D current mapping, they were divided into 2 groups (Group-A with Uni-directional pattern and Group-B with Multi-directional pattern). We compared clinical and echocardiographic characteristics at 6 months after CRT implantation. CRT responder was defined when >10% LVDd decrease or >10% LVEF increase was recognized. Results: There were no significant differences between the groups in baseline LVDd, LVEF, BNP, and NYHA. After 6 months, we found 12 responders out of 13 Group-A patients and 9 non-responders out of 12 Group-B patients (p=0.001). During the follow-up of 721±339 days, cardiac events occurred less frequently occurred in Group-A (only 1 HF hospitalization) vs. Group-B (1 death, 2 LVAS implant, 5 HF hospitalization). Conclusions: MCG can predict the CRT response and long-term prognosis after CRT.

Original languageEnglish
JournalJournal of Arrhythmia
Volume27
DOIs
Publication statusPublished - 2011

Keywords

  • CRT
  • MCG
  • heart failure

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