Magnetoencephalography (MEG): Its application to moyamoya disease

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The re-build-up phenomenon in electroencephalography (EEG) was first described as a pathognomonic phenomenon of moyamoya disease in 1977 (in Japanese) [1] and in 1979 (in English) [2]. Slow wave discharges are known to build-up during hyperventilation used as a routine provocation method in clinical EEG. Moreover, slow wave discharges also appear a few minutes after the termination of hyperventilation exclusively in patients with moyamoya disease. This re-build-up phenomenon was once thought to occur only in pediatric patients [1, 2], but was later also found in adult patients. Interestingly, the re-build-up phenomenon is often accompanied by ischemic symptoms. However, the cortical or deep structural origin of the generator mechanism remains controversial.

Original languageEnglish
Title of host publicationMoyamoya Disease Update
PublisherSpringer Japan
Number of pages5
ISBN (Print)9784431997023
Publication statusPublished - 2010


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