TY - JOUR
T1 - Margination of red blood cells infected by Plasmodium falciparum in a microvessel
AU - Imai, Yohsuke
AU - Nakaaki, Keita
AU - Kondo, Hitoshi
AU - Ishikawa, Takuji
AU - Teck Lim, Chwee
AU - Yamaguchi, Takami
N1 - Funding Information:
This research was supported by a Grant-in-Aid for Scientific Research (S) (No. 19100008 ), by a Grant-in-Aid for Young Scientists (B) (No. 20700373 ) from the JSPS, and by 2007 the Tohoku University Global COE Program Global Nano-Biomedical Engineering Education and Research Network Center. We also acknowledge support from the Global Enterprise for Micro-Mechanics and Molecular Medicine (GEM4) Laboratory at the National University of Singapore.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/5/17
Y1 - 2011/5/17
N2 - We investigated numerically the mechanism of margination of Plasmodium falciparum malaria-infected red blood cells (Pf-IRBCs) in micro-scale blood flow. Our model illustrates that continuous hydrodynamic interaction between a Pf-IRBC in the trophozoite stage (Pf-T-IRBC) and healthy red blood cells (HRBCs) results in the margination of the Pf-T-IRBC and, thus, a longer duration of contact with endothelial cells. The Pf-T-IRBC and HRBCs first form a "train". The volume fraction of RBCs is then locally increased, to approximately 40%, and this value is maintained for a long period of time due to the formation of a long train in high-hematocrit conditions. Even in low-hematocrit conditions, the local volume fraction is instantaneously elevated to 40% and the Pf-T-IRBC can migrate to the wall. However, the short train formed in low-hematocrit conditions does not provide continuous interaction, and the Pf-T-IRBC moves back to the center of the channel.
AB - We investigated numerically the mechanism of margination of Plasmodium falciparum malaria-infected red blood cells (Pf-IRBCs) in micro-scale blood flow. Our model illustrates that continuous hydrodynamic interaction between a Pf-IRBC in the trophozoite stage (Pf-T-IRBC) and healthy red blood cells (HRBCs) results in the margination of the Pf-T-IRBC and, thus, a longer duration of contact with endothelial cells. The Pf-T-IRBC and HRBCs first form a "train". The volume fraction of RBCs is then locally increased, to approximately 40%, and this value is maintained for a long period of time due to the formation of a long train in high-hematocrit conditions. Even in low-hematocrit conditions, the local volume fraction is instantaneously elevated to 40% and the Pf-T-IRBC can migrate to the wall. However, the short train formed in low-hematocrit conditions does not provide continuous interaction, and the Pf-T-IRBC moves back to the center of the channel.
KW - Hydrodynamic interaction
KW - Malaria
KW - Margination
KW - Numerical simulation
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U2 - 10.1016/j.jbiomech.2011.02.084
DO - 10.1016/j.jbiomech.2011.02.084
M3 - Article
C2 - 21420683
AN - SCOPUS:79955485247
SN - 0021-9290
VL - 44
SP - 1553
EP - 1558
JO - Journal of Biomechanics
JF - Journal of Biomechanics
IS - 8
ER -
