An extracellular polysaccharide from the marine microalga dinoflagellate Gymnodinium sp. A3, which was a D-galactan sulfate associated with L(+)-lactic acid, showed cytotoxicities to various human lymphoid cells, especially to MT-4 cells (CC50 2.67 μm/ml). Close observations of morphological change, flow cytometry, and in situ end-labeling of fragmentated DNA revealed the mechanism of cytotoxicity of this polymer to be based on the induction of apoptosis.
|Number of pages||4|
|Journal||Journal of Marine Biotechnology|
|Publication status||Published - 1998|