Marine microalgal polysaccharide induces apoptosis in human lymphoid cells

Kenichi Sogawa, Eiichi Kodama, Masahiro Matsuda, Shiro Shigeta, Koichi Okutani

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


An extracellular polysaccharide from the marine microalga dinoflagellate Gymnodinium sp. A3, which was a D-galactan sulfate associated with L(+)-lactic acid, showed cytotoxicities to various human lymphoid cells, especially to MT-4 cells (CC50 2.67 μm/ml). Close observations of morphological change, flow cytometry, and in situ end-labeling of fragmentated DNA revealed the mechanism of cytotoxicity of this polymer to be based on the induction of apoptosis.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalJournal of Marine Biotechnology
Issue number1
Publication statusPublished - 1998


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