Marine microalgal polysaccharide induces apoptosis in human lymphoid cells

Kenichi Sogawa; Eiichi Kodama; Masahiro Matsuda; Shiro Shigeta; Koichi Okutani

Marine microalgal polysaccharide induces apoptosis in human lymphoid cells

Kenichi Sogawa, Eiichi Kodama, Masahiro Matsuda, Shiro Shigeta, Koichi Okutani

IRIDeS - Disaster Medical Science Division

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

An extracellular polysaccharide from the marine microalga dinoflagellate Gymnodinium sp. A3, which was a D-galactan sulfate associated with L(+)-lactic acid, showed cytotoxicities to various human lymphoid cells, especially to MT-4 cells (CC₅₀ 2.67 μm/ml). Close observations of morphological change, flow cytometry, and in situ end-labeling of fragmentated DNA revealed the mechanism of cytotoxicity of this polymer to be based on the induction of apoptosis.

Original language	English
Pages (from-to)	35-38
Number of pages	4
Journal	Journal of Marine Biotechnology
Volume	6
Issue number	1
Publication status	Published - 1998

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abstract = "An extracellular polysaccharide from the marine microalga dinoflagellate Gymnodinium sp. A3, which was a D-galactan sulfate associated with L(+)-lactic acid, showed cytotoxicities to various human lymphoid cells, especially to MT-4 cells (CC50 2.67 μm/ml). Close observations of morphological change, flow cytometry, and in situ end-labeling of fragmentated DNA revealed the mechanism of cytotoxicity of this polymer to be based on the induction of apoptosis.",

author = "Kenichi Sogawa and Eiichi Kodama and Masahiro Matsuda and Shiro Shigeta and Koichi Okutani",

year = "1998",

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T1 - Marine microalgal polysaccharide induces apoptosis in human lymphoid cells

AU - Sogawa, Kenichi

AU - Kodama, Eiichi

AU - Matsuda, Masahiro

AU - Shigeta, Shiro

AU - Okutani, Koichi

PY - 1998

Y1 - 1998

N2 - An extracellular polysaccharide from the marine microalga dinoflagellate Gymnodinium sp. A3, which was a D-galactan sulfate associated with L(+)-lactic acid, showed cytotoxicities to various human lymphoid cells, especially to MT-4 cells (CC50 2.67 μm/ml). Close observations of morphological change, flow cytometry, and in situ end-labeling of fragmentated DNA revealed the mechanism of cytotoxicity of this polymer to be based on the induction of apoptosis.

AB - An extracellular polysaccharide from the marine microalga dinoflagellate Gymnodinium sp. A3, which was a D-galactan sulfate associated with L(+)-lactic acid, showed cytotoxicities to various human lymphoid cells, especially to MT-4 cells (CC50 2.67 μm/ml). Close observations of morphological change, flow cytometry, and in situ end-labeling of fragmentated DNA revealed the mechanism of cytotoxicity of this polymer to be based on the induction of apoptosis.

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Marine microalgal polysaccharide induces apoptosis in human lymphoid cells

Abstract

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