Maternal birth weight as an indicator of early and late gestational diabetes mellitus: The Japan Environment and Children's Study

Aims: This study aimed to investigate the association of maternal birth weight (MBW) with early and late gestational diabetes mellitus (GDM). Methods: A total of 69318 pregnant Japanese women were included in this birth cohort study. The associations between maternal birth weight and early gestational diabetes mellitus (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were investigated using a multinomial logistic regression model, with an maternal birth weight of 3000–3499 g as the reference category. Results: Lower maternal birth weight was associated with higher odds of developing early and late gestational diabetes mellitus (P < 0.0001 and P < 0.0001, respectively). The adjusted odds ratios (aORs) for early gestational diabetes mellitus in participants with a MBW of <2500 g and 2500–2999 g were 1.345 (95% confidence interval [CI]: 0.912–1.984) and 1.338 (95% CI: 1.098–1.629), respectively. The aORs for late gestational diabetes mellitus in participants with a MBW of <2500 g and 2500–2999 g were, 1.657 (95% CI: 1.298–2.115) and 1.218 (95% CI: 1.058–1.402), respectively. Conclusions: Regardless of the gestational age when gestational diabetes mellitus was diagnosed, a lower maternal birth weight was associated with an increased risk of gestational diabetes mellitus. Furthermore, the association of a MBW <2500 g with late gestational diabetes mellitus tended to be stronger than that with early gestational diabetes mellitus.