TY - JOUR
T1 - Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice
AU - Sakayori, Nobuyuki
AU - Katakura, Masanori
AU - Hamazaki, Kei
AU - Higuchi, Oki
AU - Fujii, Kazuki
AU - Fukabori, Ryoji
AU - Iguchi, Yoshio
AU - Setogawa, Susumu
AU - Takao, Keizo
AU - Miyazawa, Teruo
AU - Arita, Makoto
AU - Kobayashi, Kazuto
N1 - Funding Information:
The authors thank Dr. Mie Honda at RIKEN for assisting with the LC/MS/MS analysis; Dr. Takahiro Eitsuka at Tohoku University for providing technical advice; Ms. Chiaki Kanno and Minako Kikuchi at Fukushima Medical University for animal care; and Nisshin Oillio Group, Ltd. (Tokyo, Japan) for providing the high-linoleic safflower oil. This work was supported by JSPS KAKENHI Grant Numbers JP16H06276, JP17H06059, JP17J10395, JP19H05023, and JP19K20184 (to N.S.), the Grant for Young Scientists from the Japan Society of Nutrition and Food Science (to N.S.), and the Otsuka Award from the Japan Society for Lipid Nutrition (to N.S.).
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The increasing prevalence of obesity and its effects on our society warrant intensifying basic animal research for understanding why habitual intake of highly palatable foods has increased due to recent global environmental changes. Here, we report that pregnant mice that consume a diet high in omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and low in omega-3 (n-3) PUFAs (an n-6high/n-3low diet), whose n-6/n-3 ratio is approximately 120, induces hedonic consumption in the offspring by upregulating the midbrain dopaminergic system. We found that exposure to the n-6high/n-3low diet specifically increases the consumption of palatable foods via increased mesolimbic dopamine release. In addition, neurodevelopmental analyses revealed that this induced hedonic consumption is programmed during embryogenesis, as dopaminergic neurogenesis is increased during in utero access to the n-6high/n-3low diet. Our findings reveal that maternal consumption of PUFAs can have long-lasting effects on the offspring’s pattern for consuming highly palatable foods.
AB - The increasing prevalence of obesity and its effects on our society warrant intensifying basic animal research for understanding why habitual intake of highly palatable foods has increased due to recent global environmental changes. Here, we report that pregnant mice that consume a diet high in omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and low in omega-3 (n-3) PUFAs (an n-6high/n-3low diet), whose n-6/n-3 ratio is approximately 120, induces hedonic consumption in the offspring by upregulating the midbrain dopaminergic system. We found that exposure to the n-6high/n-3low diet specifically increases the consumption of palatable foods via increased mesolimbic dopamine release. In addition, neurodevelopmental analyses revealed that this induced hedonic consumption is programmed during embryogenesis, as dopaminergic neurogenesis is increased during in utero access to the n-6high/n-3low diet. Our findings reveal that maternal consumption of PUFAs can have long-lasting effects on the offspring’s pattern for consuming highly palatable foods.
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U2 - 10.1038/s42003-020-01209-4
DO - 10.1038/s42003-020-01209-4
M3 - Article
C2 - 32859990
AN - SCOPUS:85089994371
SN - 2399-3642
VL - 3
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 473
ER -
