TY - JOUR
T1 - Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring
T2 - the Japan Environment and Children's Study
AU - The Japan Environment and Children’s Study Group
AU - Suzuki, Taeko
AU - Nishigori, Toshie
AU - Obara, Taku
AU - Masumoto, Toshio
AU - Mori, Miyuki
AU - Murata, Tsuyoshi
AU - Kyozuka, Hyo
AU - Ogata, Yuka
AU - Sato, Akiko
AU - Sampei, Mari
AU - Takahashi, Toshifumi
AU - Shinoki, Kosei
AU - Hosoya, Mitsuaki
AU - Fujimori, Keiya
AU - Yasumura, Seiji
AU - Hashimoto, Koichi
AU - Goto, Aya
AU - Nishigori, Hidekazu
N1 - Funding Information:
The authors are grateful to all the participants of the study. Members of the JECS group as of 2021 include Michihiro Kamijima (principal investigator, Nagoya City University, Nagoya, Japan), Shin Yamazaki (National Institute for Environmental Studies, Tsukuba, Japan), Yukihiro Ohya (National Center for Child Health and Development, Tokyo, Japan), Reiko Kishi (Hokkaido University, Sapporo, Japan), Nobuo Yaegashi (Tohoku University, Sendai, Japan), Koichi Hashimoto (Fukushima Medical University, Fukushima, Japan), Chisato Mori (Chiba University, Chiba, Japan), Shuichi Ito (Yokohama City University, Yokohama, Japan), Zentaro Yamagata (University of Yamanashi, Chuo, Japan), Hidekuni Inadera (University of Toyama, Toyama, Japan), Takeo Nakayama (Kyoto University, Kyoto, Japan), Hiroyasu Iso (Osaka University, Suita, Japan), Masayuki Shima (Hyogo College of Medicine, Nishinomiya, Japan), Youichi Kurozawa (Tottori University, Yonago, Japan), Narufumi Suganuma (Kochi University, Nankoku, Japan), Koichi Kusuhara (University of Occupational and Environmental Health, Kitakyushu, Japan) and Takahiko Katoh (Kumamoto University, Kumamoto, Japan). This study was funded by the Ministry of the Environment, Japan. The findings and conclusions of this article are solely the responsibility of the authors and do not represent the official views of the above government.
Publisher Copyright:
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society.
PY - 2022/12/28
Y1 - 2022/12/28
N2 - We evaluated the association between maternal prenatal folic acid supplementation/dietary folate intake and motor and cognitive development in 2-year-old offspring using data from the Japan Environment and Children's Study database. Neurodevelopment of 2-year-old offspring were evaluated using the Kyoto Scale of Psychological Development 2001. In total, data of 3839 offspring were analysed. For folic acid supplementation, a multiple regression analysis showed that offspring of mothers who started using folic acid supplements before conception had a significantly lower developmental quotient (DQ) in the postural-motor DQ area than offspring of mothers who did not use them at any time throughout their pregnancy (partial regression coefficient (B) -2·596, 95 % CI -4·738, -0·455). Regarding daily dietary folate intake from preconception to early pregnancy, a multiple regression analysis showed that the group with ≥ 200 μg had a significantly higher DQ in the language-social area than the group with <200 μg. The DQ was higher in the ≥ 400 μg group (B 2·532, 95 % CI 0·201, 4·863) than the 200 to <400 μg group (B 1·437, 95 % CI 0·215, 2·660). In conclusion, our study showed that maternal adequate dietary folate intake from preconception to early pregnancy has a beneficial association with verbal cognition development in 2-year-old offspring. On the other hand, mothers who started using folic acid supplements before conception had an inverse association with motor development in 2-year-old offspring. There were no details on the amount of folic acid in the supplements used and frequency of use. Therefore, further studies are required.
AB - We evaluated the association between maternal prenatal folic acid supplementation/dietary folate intake and motor and cognitive development in 2-year-old offspring using data from the Japan Environment and Children's Study database. Neurodevelopment of 2-year-old offspring were evaluated using the Kyoto Scale of Psychological Development 2001. In total, data of 3839 offspring were analysed. For folic acid supplementation, a multiple regression analysis showed that offspring of mothers who started using folic acid supplements before conception had a significantly lower developmental quotient (DQ) in the postural-motor DQ area than offspring of mothers who did not use them at any time throughout their pregnancy (partial regression coefficient (B) -2·596, 95 % CI -4·738, -0·455). Regarding daily dietary folate intake from preconception to early pregnancy, a multiple regression analysis showed that the group with ≥ 200 μg had a significantly higher DQ in the language-social area than the group with <200 μg. The DQ was higher in the ≥ 400 μg group (B 2·532, 95 % CI 0·201, 4·863) than the 200 to <400 μg group (B 1·437, 95 % CI 0·215, 2·660). In conclusion, our study showed that maternal adequate dietary folate intake from preconception to early pregnancy has a beneficial association with verbal cognition development in 2-year-old offspring. On the other hand, mothers who started using folic acid supplements before conception had an inverse association with motor development in 2-year-old offspring. There were no details on the amount of folic acid in the supplements used and frequency of use. Therefore, further studies are required.
KW - Cognitive development
KW - Developmental quotient
KW - Folate
KW - Folic acid
KW - Neurodevelopment
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U2 - 10.1017/S000711452200037X
DO - 10.1017/S000711452200037X
M3 - Article
C2 - 35115066
AN - SCOPUS:85124711714
SN - 0007-1145
VL - 128
SP - 2480
EP - 2489
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 12
ER -