Mayer waves in dogs with total artificial heart

T. Yambe, S. Nitta, Y. Katahira, T. Sonobe, S. Naganuma, Y. Kakinuma, S. Kobayashi, M. Tanaka, M. Miura, N. Sato, H. Mohri, M. Yoshizawa, K. Izumi, H. Takeda

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


To assess the effect of a total artificial heart (TAH) on the autonomic nervous system a power spectral analysis of the hemodynamics in a TAH animal was done by the maximum entropy method. Two pneumatically driven sac-type ventricular assist devices were implanted as total biventricular bypass (BVB) in adult mongrel dogs to compare the differences between natural heart and TAH. Once the BVB was pumping, the natural heart was electrically fibrillated to constitute the BVB-type TAH model. In the arterial pressure waveform in animals with TAH, respiratory waves were not changed (97.7 ± 24.6%) though Mayer waves were significantly decreased (47.5 ± 22.6%) compared with the animal with a natural heart. These results suggest that prosthetic hemodynamics in the TAH animal affect fluctuations in the cardiovascular system.

Original languageEnglish
Pages (from-to)601-605
Number of pages5
JournalInternational Journal of Artificial Organs
Issue number10
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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