Measurement of regional cerebral blood flow and oxygen utilisation in patients with cerebral tumours using 15O and positron emission tomography: Analytical techniques and preliminary results

M. Ito; A. A. Lammertsma; R. J.S. Wise; Silvia Bernardi; R. S.J. Frackowiak; J. D. Heather; C. G. McKenzie; D. G.T. Thomas; T. Jones

doi:10.1007/BF00367239

Measurement of regional cerebral blood flow and oxygen utilisation in patients with cerebral tumours using ¹⁵O and positron emission tomography: Analytical techniques and preliminary results

M. Ito, A. A. Lammertsma, R. J.S. Wise, Silvia Bernardi, R. S.J. Frackowiak, J. D. Heather, C. G. McKenzie, D. G.T. Thomas, T. Jones

Cyclotron and Radioisotope Center (CYRIC)

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

Regional cerebral blood flow and oxygen utilisation have been studied in 8 patients with brain tumours using continuous inhalation of C¹⁵O₂ and ¹⁵O₂ and positron emission tomography. The methods used to analyse the regional cerebral pathophysiology are presented. A relative uncoupling between oxygen consumption and blood flow was observed in all tumours as indicated by a decreased regional fractional extraction of oxygen (rOER). This suggests that a major proportion of these tumours had sufficient blood supply to meet oxygen metabolic demand. A decrease of blood flow in grey matter was found both in the affected and contralateral hemispheres of the brain. Matched reductions of flow and oxygen utilisation were observed in oedematous tissue.

Original language	English
Pages (from-to)	63-74
Number of pages	12
Journal	Neuroradiology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1007/BF00367239
Publication status	Published - 1982 Apr

Keywords

Cerebral blood flow
Cerebral oedema
Cerebral oxygen utilisation
Cerebral tumours
Positron emission tomography

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology
Cardiology and Cardiovascular Medicine

Access to Document

10.1007/BF00367239

Cite this

Ito, M., Lammertsma, A. A., Wise, R. J. S., Bernardi, S., Frackowiak, R. S. J., Heather, J. D., McKenzie, C. G., Thomas, D. G. T., & Jones, T. (1982). Measurement of regional cerebral blood flow and oxygen utilisation in patients with cerebral tumours using ¹⁵O and positron emission tomography: Analytical techniques and preliminary results. Neuroradiology, 23(2), 63-74. https://doi.org/10.1007/BF00367239

Ito, M, Lammertsma, AA, Wise, RJS, Bernardi, S, Frackowiak, RSJ, Heather, JD, McKenzie, CG, Thomas, DGT & Jones, T 1982, 'Measurement of regional cerebral blood flow and oxygen utilisation in patients with cerebral tumours using ¹⁵O and positron emission tomography: Analytical techniques and preliminary results', Neuroradiology, vol. 23, no. 2, pp. 63-74. https://doi.org/10.1007/BF00367239

@article{a99843bcc802486ba86924e43bbad8b9,

title = "Measurement of regional cerebral blood flow and oxygen utilisation in patients with cerebral tumours using 15O and positron emission tomography: Analytical techniques and preliminary results",

abstract = "Regional cerebral blood flow and oxygen utilisation have been studied in 8 patients with brain tumours using continuous inhalation of C15O2 and 15O2 and positron emission tomography. The methods used to analyse the regional cerebral pathophysiology are presented. A relative uncoupling between oxygen consumption and blood flow was observed in all tumours as indicated by a decreased regional fractional extraction of oxygen (rOER). This suggests that a major proportion of these tumours had sufficient blood supply to meet oxygen metabolic demand. A decrease of blood flow in grey matter was found both in the affected and contralateral hemispheres of the brain. Matched reductions of flow and oxygen utilisation were observed in oedematous tissue.",

keywords = "Cerebral blood flow, Cerebral oedema, Cerebral oxygen utilisation, Cerebral tumours, Positron emission tomography",

author = "M. Ito and Lammertsma, {A. A.} and Wise, {R. J.S.} and Silvia Bernardi and Frackowiak, {R. S.J.} and Heather, {J. D.} and McKenzie, {C. G.} and Thomas, {D. G.T.} and T. Jones",

year = "1982",

month = apr,

doi = "10.1007/BF00367239",

language = "English",

volume = "23",

pages = "63--74",

journal = "Neuroradiology",

issn = "0028-3940",

publisher = "Springer Verlag",

number = "2",

}

TY - JOUR

T1 - Measurement of regional cerebral blood flow and oxygen utilisation in patients with cerebral tumours using 15O and positron emission tomography

T2 - Analytical techniques and preliminary results

AU - Ito, M.

AU - Lammertsma, A. A.

AU - Wise, R. J.S.

AU - Bernardi, Silvia

AU - Frackowiak, R. S.J.

AU - Heather, J. D.

AU - McKenzie, C. G.

AU - Thomas, D. G.T.

AU - Jones, T.

PY - 1982/4

Y1 - 1982/4

N2 - Regional cerebral blood flow and oxygen utilisation have been studied in 8 patients with brain tumours using continuous inhalation of C15O2 and 15O2 and positron emission tomography. The methods used to analyse the regional cerebral pathophysiology are presented. A relative uncoupling between oxygen consumption and blood flow was observed in all tumours as indicated by a decreased regional fractional extraction of oxygen (rOER). This suggests that a major proportion of these tumours had sufficient blood supply to meet oxygen metabolic demand. A decrease of blood flow in grey matter was found both in the affected and contralateral hemispheres of the brain. Matched reductions of flow and oxygen utilisation were observed in oedematous tissue.

AB - Regional cerebral blood flow and oxygen utilisation have been studied in 8 patients with brain tumours using continuous inhalation of C15O2 and 15O2 and positron emission tomography. The methods used to analyse the regional cerebral pathophysiology are presented. A relative uncoupling between oxygen consumption and blood flow was observed in all tumours as indicated by a decreased regional fractional extraction of oxygen (rOER). This suggests that a major proportion of these tumours had sufficient blood supply to meet oxygen metabolic demand. A decrease of blood flow in grey matter was found both in the affected and contralateral hemispheres of the brain. Matched reductions of flow and oxygen utilisation were observed in oedematous tissue.

KW - Cerebral blood flow

KW - Cerebral oedema

KW - Cerebral oxygen utilisation

KW - Cerebral tumours

KW - Positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=0020025912&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020025912&partnerID=8YFLogxK

U2 - 10.1007/BF00367239

DO - 10.1007/BF00367239

M3 - Article

C2 - 6979003

AN - SCOPUS:0020025912

SN - 0028-3940

VL - 23

SP - 63

EP - 74

JO - Neuroradiology

JF - Neuroradiology

IS - 2

ER -