Mechanical strength and biocompatibility of meta-stable β type Ti-5Fe-3Nb-3Zr for biomedical applications

Keisuke Ushida, Kenta Tsuge, Toshikazu Akahori, Tomokazu Hattori, Mitsuo Niinomi, Kei Ishikura, Mohamed A.H. Gepreel

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Ti-29Nb-13Ta-4.6Zr (TNTZ) is a very attractive material for biomedical applications because of its low Young's modulus. However, this alloy contains a certain amount of rare-metals elements. In this study, Ti-Fe-Nb-Zr system alloys were developed by substituting Fe for Ta as the low cost β stabilizer, and the mechanical properties and biocompatibility of these alloys were investigated for five different compositions through thermo-mechanical treatments. The micro-Vickers hardness of the Ti-Fe-Nb-Zr system alloy decreases with Fe addition up to 7 mol% because of the suppression of the ω-phase precipitate. Subsequently, it increases by further Fe addition due to solid-solution strengthening. Ti-5Fe-3Nb-3Zr (Ti-5-3-3) subjected to solution treatment (ST) shows the lowest Young's modulus among the other composition. In addition, the tensile strength of Ti-5-3-3 subjected to ST is higher than those of the annealed Ti-6Al-4V ELI and TNTZ subjected to ST. The specimens of the alloy implanted in the femoral epicondyle of rabbit are surrounded by new bone tissue formed with direct contact after 24 and 48 weeks from the implantation. It is considered that Ti-5-3-3 has relatively good biocompatibility with contact osteo-genesis as compared with those of Ti-6Al-4V ELI and SUS316L stainless steel.

Original languageEnglish
Pages (from-to)397-401
Number of pages5
JournalNippon Kinzoku Gakkaishi/Journal of the Japan Institute of Metals
Issue number6
Publication statusPublished - 2012 Jun


  • Bone-compatibility
  • Low cost titanium alloy
  • Mechanical properties
  • Metallic biomaterial

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Mechanics of Materials
  • Metals and Alloys
  • Materials Chemistry


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