Mechanism of development and countermeasure for radiation-induced myocardial disorder

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Recently, there have been many reports of patients with radiation-induced myocardial disorder in the late phase. Radiation-induced microvascular damage to the myocardium occurred as a result of the direct effects of radiation on endothelial cells of capillaries of < 0.2 mm in diameter within the myocardium. Radiation-induced myocardial disorder is related with dose-volume histogram. Thus, multiportal irradiation, intensity-modulated radiotherapy and particle beam irradiation are effective to reduce irradiated dose and volume in heart. Natriuretic peptide, ACE inhibitor and lifestyle guidance might have protective value for radiation-induced myocardial disorder: however, there is no definitive evidence clinically.

Original languageEnglish
Pages (from-to)1221-1224
Number of pages4
JournalJapanese Journal of Clinical Radiology
Issue number10
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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