Mechanisms of leukocyte trafficking in allergic diseases: Insights into new therapies targeting chemokines and chemokine receptors

Masako Toda; Takao Nakamura; Masaharu Ohbayashi; Yoshifumi Ikeda; Maria Dawson; Cho Cho Aye; Dai Miyazaki; Santa Jeremy Ono

doi:10.1586/1744666X.3.3.351

Mechanisms of leukocyte trafficking in allergic diseases: Insights into new therapies targeting chemokines and chemokine receptors

Masako Toda, Takao Nakamura, Masaharu Ohbayashi, Yoshifumi Ikeda, Maria Dawson, Cho Cho Aye, Dai Miyazaki, Santa Jeremy Ono

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

Abstract

Marked inflammatory infiltration by activated leukocytes; is a characteristic feature of allergic diseases. Elucidation of the mechanisms of leukocyte trafficking in allergic diseases would identity targets to establish novel anti-inflammatory strategies for treatment of these diseases. Leukocyte trafficking is controlled by tissue-specific expression of chemokines and chemokine receptor expression on the leukocyte, surface. Here, we review the role of chemokines and their receptors in leukocyte trafficking to inflammatory sites in allergic diseases and discuss therapeutic strategies targeting chemokine networks for treatment of these diseases.

Original language	English
Pages (from-to)	351-364
Number of pages	14
Journal	Expert Review of Clinical Immunology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1586/1744666X.3.3.351
Publication status	Published - 2007 May 1
Externally published	Yes

Keywords

Allergic disease
Chemokine
Chemokine receptor
Leukocyte trafficking

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1586/1744666X.3.3.351

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title = "Mechanisms of leukocyte trafficking in allergic diseases: Insights into new therapies targeting chemokines and chemokine receptors",

abstract = "Marked inflammatory infiltration by activated leukocytes; is a characteristic feature of allergic diseases. Elucidation of the mechanisms of leukocyte trafficking in allergic diseases would identity targets to establish novel anti-inflammatory strategies for treatment of these diseases. Leukocyte trafficking is controlled by tissue-specific expression of chemokines and chemokine receptor expression on the leukocyte, surface. Here, we review the role of chemokines and their receptors in leukocyte trafficking to inflammatory sites in allergic diseases and discuss therapeutic strategies targeting chemokine networks for treatment of these diseases.",

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author = "Masako Toda and Takao Nakamura and Masaharu Ohbayashi and Yoshifumi Ikeda and Maria Dawson and Aye, {Cho Cho} and Dai Miyazaki and Ono, {Santa Jeremy}",

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T2 - Insights into new therapies targeting chemokines and chemokine receptors

AU - Toda, Masako

AU - Nakamura, Takao

AU - Ohbayashi, Masaharu

AU - Ikeda, Yoshifumi

AU - Dawson, Maria

AU - Aye, Cho Cho

AU - Miyazaki, Dai

AU - Ono, Santa Jeremy

PY - 2007/5/1

Y1 - 2007/5/1

N2 - Marked inflammatory infiltration by activated leukocytes; is a characteristic feature of allergic diseases. Elucidation of the mechanisms of leukocyte trafficking in allergic diseases would identity targets to establish novel anti-inflammatory strategies for treatment of these diseases. Leukocyte trafficking is controlled by tissue-specific expression of chemokines and chemokine receptor expression on the leukocyte, surface. Here, we review the role of chemokines and their receptors in leukocyte trafficking to inflammatory sites in allergic diseases and discuss therapeutic strategies targeting chemokine networks for treatment of these diseases.

AB - Marked inflammatory infiltration by activated leukocytes; is a characteristic feature of allergic diseases. Elucidation of the mechanisms of leukocyte trafficking in allergic diseases would identity targets to establish novel anti-inflammatory strategies for treatment of these diseases. Leukocyte trafficking is controlled by tissue-specific expression of chemokines and chemokine receptor expression on the leukocyte, surface. Here, we review the role of chemokines and their receptors in leukocyte trafficking to inflammatory sites in allergic diseases and discuss therapeutic strategies targeting chemokine networks for treatment of these diseases.

KW - Allergic disease

KW - Chemokine

KW - Chemokine receptor

KW - Leukocyte trafficking

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Mechanisms of leukocyte trafficking in allergic diseases: Insights into new therapies targeting chemokines and chemokine receptors

Abstract

Keywords

ASJC Scopus subject areas

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