Cells change gene expression when they differentiate into different cell lineages. Cells also change their gene expression profiles to adapt to altering milieus. Even physical forces(for example, forces evoked by muscle contraction or exercise)change gene expression dramatically, although the molecular mechanisms of this physico-genetic link are largely unknown. Here, we summarize several works published recently, trying to highlight the physical force as an essential parameter of gene expression and maintenance of homeostasis.
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|Published - 2016 Jan 1