Menstrual cycle dependent expression of CD44 in normal human endometrium

Nobuo Yaegashi, Nobuhiro Fujita, Akira Yajima, Masataka Nakamura

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


CD44 is a cell surface glycoprotein known to be a hyaluronate receptor, which functions in lymphocyte homing and cancer metastasis. We have previously shown that CD44 molecules are expressed in normal endometrial tissue. In this study we immunohistochemically examined expression of CD44 glycoproteins in normal human endometrial tissue to gain insight into roles of CD44 molecules. No expression of the CD44 standard form was observed with 11 endometria in the proliferative phase. On the contrary, 13 of 19 secretory phase endometria were stained intensely by anti-CD44 standard form antibody; all CD44-positive cases were in the mid and late secretory phases. Among the 13 CD44-positive endometria, four also were positive for the CD44 variant with exon v6. CD44 molecules were present at all but the luminal cell surfaces. These results indicate that expression of CD44 depends on menstrual cycle, suggesting that CD44 molecules might be involved in implantation of fertilized ovum in endometrium.

Original languageEnglish
Pages (from-to)862-865
Number of pages4
JournalHuman Pathology
Issue number8
Publication statusPublished - 1995 Aug


  • CD44
  • endometrium
  • menstruation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


Dive into the research topics of 'Menstrual cycle dependent expression of CD44 in normal human endometrium'. Together they form a unique fingerprint.

Cite this