Merkel cell carcinoma concomitant with invasive Bowen's disease: Immunohistochemical investigation of tumor-infiltrating leukocytes

Hisayuki Tono; Taku Fujimura; Eimei Iwama; Yoshiyuki Kusakari; Sadanori Furudate; Yumi Kambayashi; Takahiro Haga; Akira Hashimoto; Setsuya Aiba

doi:10.1159/000371732

Merkel cell carcinoma concomitant with invasive Bowen's disease: Immunohistochemical investigation of tumor-infiltrating leukocytes

Hisayuki Tono, Taku Fujimura, Eimei Iwama, Yoshiyuki Kusakari, Sadanori Furudate, Yumi Kambayashi, Takahiro Haga, Akira Hashimoto, Setsuya Aiba

Tohoku University

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Merkel cell carcinoma (MCC) is an aggressive, cutaneous, neuroendocrine carcinoma and, in rare cases, occurs with Bowen's disease (BD). In this report, we describe a case of MCC concurrent with invasive BD and compare the profiles of tumor-infiltrating leukocytes in the lesional skin of MCC and invasive BD. Interestingly, immunohistochemical study revealed significant numbers of CD8+ cells and caspase 3-expressing cells in the same areas of invasive BD and MCC. Our present case suggests that MCC concurrent with invasive BD might have a good prognosis because of the substantial number of CD8+ cells in the tumor.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Case Reports in Dermatology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1159/000371732
Publication status	Published - 2015 May 22

Keywords

CD8
Caspase 3
Invasive Bowen's disease
Merkel cell carcinoma
Tumor-infiltrating leukocytes

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10.1159/000371732

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title = "Merkel cell carcinoma concomitant with invasive Bowen's disease: Immunohistochemical investigation of tumor-infiltrating leukocytes",

abstract = "Merkel cell carcinoma (MCC) is an aggressive, cutaneous, neuroendocrine carcinoma and, in rare cases, occurs with Bowen's disease (BD). In this report, we describe a case of MCC concurrent with invasive BD and compare the profiles of tumor-infiltrating leukocytes in the lesional skin of MCC and invasive BD. Interestingly, immunohistochemical study revealed significant numbers of CD8+ cells and caspase 3-expressing cells in the same areas of invasive BD and MCC. Our present case suggests that MCC concurrent with invasive BD might have a good prognosis because of the substantial number of CD8+ cells in the tumor.",

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AU - Tono, Hisayuki

AU - Fujimura, Taku

AU - Iwama, Eimei

AU - Kusakari, Yoshiyuki

AU - Furudate, Sadanori

AU - Kambayashi, Yumi

AU - Haga, Takahiro

AU - Hashimoto, Akira

AU - Aiba, Setsuya

PY - 2015/5/22

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N2 - Merkel cell carcinoma (MCC) is an aggressive, cutaneous, neuroendocrine carcinoma and, in rare cases, occurs with Bowen's disease (BD). In this report, we describe a case of MCC concurrent with invasive BD and compare the profiles of tumor-infiltrating leukocytes in the lesional skin of MCC and invasive BD. Interestingly, immunohistochemical study revealed significant numbers of CD8+ cells and caspase 3-expressing cells in the same areas of invasive BD and MCC. Our present case suggests that MCC concurrent with invasive BD might have a good prognosis because of the substantial number of CD8+ cells in the tumor.

AB - Merkel cell carcinoma (MCC) is an aggressive, cutaneous, neuroendocrine carcinoma and, in rare cases, occurs with Bowen's disease (BD). In this report, we describe a case of MCC concurrent with invasive BD and compare the profiles of tumor-infiltrating leukocytes in the lesional skin of MCC and invasive BD. Interestingly, immunohistochemical study revealed significant numbers of CD8+ cells and caspase 3-expressing cells in the same areas of invasive BD and MCC. Our present case suggests that MCC concurrent with invasive BD might have a good prognosis because of the substantial number of CD8+ cells in the tumor.

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Merkel cell carcinoma concomitant with invasive Bowen's disease: Immunohistochemical investigation of tumor-infiltrating leukocytes

Abstract

Keywords

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