Merkel Cell Carcinoma with Spontaneous Regression: A Case Report and Immunohistochemical Study

Hitoshi Terui; Taku Fujimura; Aya Kakizaki; Sadanori Furudate; Setsuya Aiba

doi:10.1159/000444317

Merkel Cell Carcinoma with Spontaneous Regression: A Case Report and Immunohistochemical Study

Hitoshi Terui, Taku Fujimura, Aya Kakizaki, Sadanori Furudate, Setsuya Aiba

Tohoku University

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9 Citations (Scopus)

Abstract

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma that only rarely regresses spontaneously. Since little is known about the immunological mechanisms involved in the spontaneous regression of MCC, we describe a case of MCC with spontaneous regression and employed immunohistochemical staining for cytotoxic and immunosuppressive molecules to investigate possible mechanisms involved in the spontaneous regression of MCC. Interestingly, compared to conventional MCC, tumor-infiltrating lymphocytes in MCC with spontaneous regression contained higher numbers of CD8⁺ cells and granulysin-bearing cells and lower numbers of CD206⁺ cells. Our present study suggests one of the possible reasons for the spontaneous regression of MCC.

Original language	English
Pages (from-to)	52-58
Number of pages	7
Journal	Case Reports in Dermatology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1159/000444317
Publication status	Published - 2016

Keywords

Granulysin
Merkel cell carcinoma
Spontaneous regression
Tumor-associated macrophages

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10.1159/000444317

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abstract = "Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma that only rarely regresses spontaneously. Since little is known about the immunological mechanisms involved in the spontaneous regression of MCC, we describe a case of MCC with spontaneous regression and employed immunohistochemical staining for cytotoxic and immunosuppressive molecules to investigate possible mechanisms involved in the spontaneous regression of MCC. Interestingly, compared to conventional MCC, tumor-infiltrating lymphocytes in MCC with spontaneous regression contained higher numbers of CD8+ cells and granulysin-bearing cells and lower numbers of CD206+ cells. Our present study suggests one of the possible reasons for the spontaneous regression of MCC.",

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T1 - Merkel Cell Carcinoma with Spontaneous Regression

T2 - A Case Report and Immunohistochemical Study

AU - Terui, Hitoshi

AU - Fujimura, Taku

AU - Kakizaki, Aya

AU - Furudate, Sadanori

AU - Aiba, Setsuya

PY - 2016

Y1 - 2016

N2 - Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma that only rarely regresses spontaneously. Since little is known about the immunological mechanisms involved in the spontaneous regression of MCC, we describe a case of MCC with spontaneous regression and employed immunohistochemical staining for cytotoxic and immunosuppressive molecules to investigate possible mechanisms involved in the spontaneous regression of MCC. Interestingly, compared to conventional MCC, tumor-infiltrating lymphocytes in MCC with spontaneous regression contained higher numbers of CD8+ cells and granulysin-bearing cells and lower numbers of CD206+ cells. Our present study suggests one of the possible reasons for the spontaneous regression of MCC.

AB - Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma that only rarely regresses spontaneously. Since little is known about the immunological mechanisms involved in the spontaneous regression of MCC, we describe a case of MCC with spontaneous regression and employed immunohistochemical staining for cytotoxic and immunosuppressive molecules to investigate possible mechanisms involved in the spontaneous regression of MCC. Interestingly, compared to conventional MCC, tumor-infiltrating lymphocytes in MCC with spontaneous regression contained higher numbers of CD8+ cells and granulysin-bearing cells and lower numbers of CD206+ cells. Our present study suggests one of the possible reasons for the spontaneous regression of MCC.

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KW - Merkel cell carcinoma

KW - Spontaneous regression

KW - Tumor-associated macrophages

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Merkel Cell Carcinoma with Spontaneous Regression: A Case Report and Immunohistochemical Study

Abstract

Keywords

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