TY - JOUR
T1 - Mesenchymal stem cell-based bone tissue engineering for veterinary practice
AU - Nantavisai, Sirirat
AU - Egusa, Hiroshi
AU - Osathanon, Thanaphum
AU - Sawangmake, Chenphop
N1 - Funding Information:
CS was supported by the Veterinary Clinical Stem Cell and Bioengineering Research Unit, Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University, Thailand; the Chulalongkorn University Office of International Affairs Scholarship for Short-term Research, Thailand; the Government Research Fund, Thailand; and the Asahi Foundation research grant, Japan. TO was supported by the Chulalongkorn Academic Advancement into Its 2nd Century Project, Thailand.
Funding Information:
CS was supported by the Veterinary Clinical Stem Cell and Bioengineering Research Unit, Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University , Thailand; the Chulalongkorn University Office of International Affairs Scholarship for Short-term Research , Thailand; the Government Research Fund , Thailand; and the Asahi Foundation research grant , Japan. TO was supported by the Chulalongkorn Academic Advancement into Its 2 nd Century Project, Thailand.
Publisher Copyright:
© 2019 The Author(s)
PY - 2019/11
Y1 - 2019/11
N2 - Bone tissue engineering has been widely studied and proposed as a promising platform for correcting the bone defects. The applications of mesenchymal stem cell (MSC)-based bone tissue engineering have been investigated in various in vitro and in vivo models. In this regard, the promising animal bone defect models have been employed for illustrating the bone regenerative capacity of MSC-based bone tissue engineering. However, most studies aimed for clinical applications in human. These evidences suggest a knowledge gap to fulfill the accomplishment for veterinary implementation. In this review, the fundamental concept, knowledge, and technology of MSC-based bone tissue engineering focusing on veterinary applications are summarized. In addition, the potential canine MSCs resources for veterinary bone tissue engineering are reviewed, including canine bone marrow-derived MSCs, canine adipose-derived MSCs, and canine dental tissue-derived MSCs. This review will provide a basic and current information for studies aiming for the utilization of MSC-based bone tissue engineering in veterinary practice.
AB - Bone tissue engineering has been widely studied and proposed as a promising platform for correcting the bone defects. The applications of mesenchymal stem cell (MSC)-based bone tissue engineering have been investigated in various in vitro and in vivo models. In this regard, the promising animal bone defect models have been employed for illustrating the bone regenerative capacity of MSC-based bone tissue engineering. However, most studies aimed for clinical applications in human. These evidences suggest a knowledge gap to fulfill the accomplishment for veterinary implementation. In this review, the fundamental concept, knowledge, and technology of MSC-based bone tissue engineering focusing on veterinary applications are summarized. In addition, the potential canine MSCs resources for veterinary bone tissue engineering are reviewed, including canine bone marrow-derived MSCs, canine adipose-derived MSCs, and canine dental tissue-derived MSCs. This review will provide a basic and current information for studies aiming for the utilization of MSC-based bone tissue engineering in veterinary practice.
KW - Biomedical engineering
KW - Bone tissue engineering
KW - Canine
KW - Mesenchymal stem cells
KW - Stem cell research
KW - Veterinary medicine
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U2 - 10.1016/j.heliyon.2019.e02808
DO - 10.1016/j.heliyon.2019.e02808
M3 - Review article
AN - SCOPUS:85075517053
SN - 2405-8440
VL - 5
JO - Heliyon
JF - Heliyon
IS - 11
M1 - e02808
ER -