TY - JOUR
T1 - Metabolic fate of L-[methyl-11C]methionine in human plasma
AU - Ishiwata, Kiichi
AU - Hatazawa, Jun
AU - Kubota, Kazuo
AU - Kameyama, Motonobu
AU - Itoh, Masatoshi
AU - Matsuzawa, Taiju
AU - Takahashi, Toshihiro
AU - Iwata, Ren
AU - Ido, Tatsuo
PY - 1989/10
Y1 - 1989/10
N2 - The metabolites of L-[methyl-11C]methionine in the plasma of 8 patients with tumor were measured for 60 min after injection. In the plasma, after a rapid clearance, the total radioactivity remained constant, and protein-bound radioactivity increased rapidly. Non protein metabolites detected by HPLC as at least two components besides methionine, increased with time. Significant individual variations for the metabolism were observed. AT 60 min after injection, 36.5% (range: 16%-72%) and 45.3% (range: 13%-74%) of the 11C was measured as methionine and labeled proteins, respectively.
AB - The metabolites of L-[methyl-11C]methionine in the plasma of 8 patients with tumor were measured for 60 min after injection. In the plasma, after a rapid clearance, the total radioactivity remained constant, and protein-bound radioactivity increased rapidly. Non protein metabolites detected by HPLC as at least two components besides methionine, increased with time. Significant individual variations for the metabolism were observed. AT 60 min after injection, 36.5% (range: 16%-72%) and 45.3% (range: 13%-74%) of the 11C was measured as methionine and labeled proteins, respectively.
KW - C-methionine
KW - Positron emission tomography
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U2 - 10.1007/BF00251681
DO - 10.1007/BF00251681
M3 - Article
C2 - 2806329
AN - SCOPUS:0024417617
SN - 0340-6997
VL - 15
SP - 665
EP - 669
JO - European Journal of Nuclear Medicine
JF - European Journal of Nuclear Medicine
IS - 10
ER -