Metabolic fate of L-[methyl-11C]methionine in human plasma

Kiichi Ishiwata, Jun Hatazawa, Kazuo Kubota, Motonobu Kameyama, Masatoshi Itoh, Taiju Matsuzawa, Toshihiro Takahashi, Ren Iwata, Tatsuo Ido

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


The metabolites of L-[methyl-11C]methionine in the plasma of 8 patients with tumor were measured for 60 min after injection. In the plasma, after a rapid clearance, the total radioactivity remained constant, and protein-bound radioactivity increased rapidly. Non protein metabolites detected by HPLC as at least two components besides methionine, increased with time. Significant individual variations for the metabolism were observed. AT 60 min after injection, 36.5% (range: 16%-72%) and 45.3% (range: 13%-74%) of the 11C was measured as methionine and labeled proteins, respectively.

Original languageEnglish
Pages (from-to)665-669
Number of pages5
JournalEuropean Journal of Nuclear Medicine
Issue number10
Publication statusPublished - 1989 Oct


  • C-methionine
  • Positron emission tomography


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