@article{c03e5d4de9f84f7596478619d5f82258,
title = "Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression",
abstract = "New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed by a total synthesis. The planar structure of 2 was determined by interpretation of spectroscopic data, whereas its absolute configuration was analyzed by a combination of chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase.",
keywords = "Cell-cycle, Marine sponge, Structure elucidation, Terpenoid",
author = "Yuki Hitora and Kentaro Takada and Yuji Ise and Woo, {Sau Pinn} and Seiya Inoue and Naoki Mori and Hirosato Takikawa and Shohei Nakamukai and Shigeru Okada and Shigeki Matsunaga",
note = "Funding Information: The sponge was collected during the NT-09-17 cruise of Natsushima, JAMSTEC Japan Agency for Marine-Earth Science and Technology. This work was supported by JSPS KAKENHI 17H06403. We thank Dr. Shibata, BD Biosciences, for measuring FACS of HeLa/Fucci2 cells. Appendix A Funding Information: The sponge was collected during the NT-09-17 cruise of Natsushima, JAMSTEC Japan Agency for Marine-Earth Science and Technology. This work was supported by JSPS KAKENHI 17H06403. We thank Dr. Shibata, BD Biosciences, for measuring FACS of HeLa/Fucci2 cells. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2020",
month = jan,
day = "15",
doi = "10.1016/j.bmc.2019.115233",
language = "English",
volume = "28",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Ltd.",
number = "2",
}
