Micafungin concentrations in the plasma and burn eschar of severely burned patients

Junichi Sasaki; Satoshi Yamanouchi; Daisuke Kudo; Tomoyuki Endo; Ryosuke Nomura; Kiyotsugu Takuma; Shigeki Kushimoto; Yotaro Shinozawa; Satoshi Kishino; Shingo Hori; Naoki Aikawa

doi:10.1128/AAC.05381-11

Micafungin concentrations in the plasma and burn eschar of severely burned patients

Junichi Sasaki, Satoshi Yamanouchi, Daisuke Kudo, Tomoyuki Endo, Ryosuke Nomura, Kiyotsugu Takuma, Shigeki Kushimoto, Yotaro Shinozawa, Satoshi Kishino, Shingo Hori, Naoki Aikawa

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Micafungin concentrations in plasma and burn eschar after daily intravenous infusion (1 h) of micafungin (200 to 300 mg) were investigated for six patients with severe burns. Micafungin treatment was initiated more than 72 h after the burn injuries. The peak and trough levels in the plasma after the initial administration and repeated administrations for more than 4 days were comparable with or slightly lower than the reported values for healthy volunteers. Micafungin concentrations in the plasma and burn eschar were between 3.6 and >1,000 times higher than the reported MIC₉₀s of micafungin against clinically important Candida and Aspergillus species.

Original language	English
Pages (from-to)	1113-1115
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	56
Issue number	2
DOIs	https://doi.org/10.1128/AAC.05381-11
Publication status	Published - 2012 Feb

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abstract = "Micafungin concentrations in plasma and burn eschar after daily intravenous infusion (1 h) of micafungin (200 to 300 mg) were investigated for six patients with severe burns. Micafungin treatment was initiated more than 72 h after the burn injuries. The peak and trough levels in the plasma after the initial administration and repeated administrations for more than 4 days were comparable with or slightly lower than the reported values for healthy volunteers. Micafungin concentrations in the plasma and burn eschar were between 3.6 and >1,000 times higher than the reported MIC90s of micafungin against clinically important Candida and Aspergillus species.",

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AU - Sasaki, Junichi

AU - Yamanouchi, Satoshi

AU - Kudo, Daisuke

AU - Endo, Tomoyuki

AU - Nomura, Ryosuke

AU - Takuma, Kiyotsugu

AU - Kushimoto, Shigeki

AU - Shinozawa, Yotaro

AU - Kishino, Satoshi

AU - Hori, Shingo

AU - Aikawa, Naoki

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AB - Micafungin concentrations in plasma and burn eschar after daily intravenous infusion (1 h) of micafungin (200 to 300 mg) were investigated for six patients with severe burns. Micafungin treatment was initiated more than 72 h after the burn injuries. The peak and trough levels in the plasma after the initial administration and repeated administrations for more than 4 days were comparable with or slightly lower than the reported values for healthy volunteers. Micafungin concentrations in the plasma and burn eschar were between 3.6 and >1,000 times higher than the reported MIC90s of micafungin against clinically important Candida and Aspergillus species.

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Micafungin concentrations in the plasma and burn eschar of severely burned patients

Abstract

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