Mice lacking histidine decarboxylase exhibit abnormal mast cells

Hiroshi Ohtsu; Satoshi Tanaka; Tadashi Terui; Yoshio Hori; Yoko Makabe-Kobayashi; Gunnar Pejler; Elena Tchougounova; Lars Hellman; Marina Gertsenstein; Noriyasu Hirasawa; Eiko Sakurai; Edit Buzás; Péter Kovács; György Csaba; Ágnes Kittel; Mikiko Okada; Masahiro Hara; Lynn Mar; Keiko Numayama-Tsuruta; Satsuki Ishigaki-Suzuki; Kazuo Ohuchi; Atsushi Ichikawa; András Falus; Takehiko Watanabe; András Nagy

doi:10.1016/S0014-5793(01)02663-1

Mice lacking histidine decarboxylase exhibit abnormal mast cells

Hiroshi Ohtsu, Satoshi Tanaka, Tadashi Terui, Yoshio Hori, Yoko Makabe-Kobayashi, Gunnar Pejler, Elena Tchougounova, Lars Hellman, Marina Gertsenstein, Noriyasu Hirasawa, Eiko Sakurai, Edit Buzás, Péter Kovács, György Csaba, Ágnes Kittel, Mikiko Okada, Masahiro Hara, Lynn Mar, Keiko Numayama-Tsuruta, Satsuki Ishigaki-SuzukiKazuo Ohuchi, Atsushi Ichikawa, András Falus, Takehiko Watanabe, András Nagy

Research output: Contribution to journal › Article › peer-review

360 Citations (Scopus)

Abstract

Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC-deficient mice using a gene targeting method. The mice showed a histamine deficiency and lacked histamine-synthesizing activity from histidine. These HDC-deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content. The amounts of mast cell granular proteases were tremendously reduced. The HDC-deficient mice provide a unique and promising model for studying the role of histamine in a broad range of normal and disease processes.

Original language	English
Pages (from-to)	53-56
Number of pages	4
Journal	FEBS Letters
Volume	502
Issue number	1-2
DOIs	https://doi.org/10.1016/S0014-5793(01)02663-1
Publication status	Published - 2001 Jul 27

Keywords

Histamine
Knockout
Mast cell
Rodent

Access to Document

10.1016/S0014-5793(01)02663-1

Cite this

Ohtsu, H., Tanaka, S., Terui, T., Hori, Y., Makabe-Kobayashi, Y., Pejler, G., Tchougounova, E., Hellman, L., Gertsenstein, M., Hirasawa, N., Sakurai, E., Buzás, E., Kovács, P., Csaba, G., Kittel, Á., Okada, M., Hara, M., Mar, L., Numayama-Tsuruta, K., ... Nagy, A. (2001). Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Letters, 502(1-2), 53-56. https://doi.org/10.1016/S0014-5793(01)02663-1

@article{948f7039eff14bc5b33b641a3f27406d,

title = "Mice lacking histidine decarboxylase exhibit abnormal mast cells",

abstract = "Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC-deficient mice using a gene targeting method. The mice showed a histamine deficiency and lacked histamine-synthesizing activity from histidine. These HDC-deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content. The amounts of mast cell granular proteases were tremendously reduced. The HDC-deficient mice provide a unique and promising model for studying the role of histamine in a broad range of normal and disease processes.",

keywords = "Histamine, Knockout, Mast cell, Rodent",

author = "Hiroshi Ohtsu and Satoshi Tanaka and Tadashi Terui and Yoshio Hori and Yoko Makabe-Kobayashi and Gunnar Pejler and Elena Tchougounova and Lars Hellman and Marina Gertsenstein and Noriyasu Hirasawa and Eiko Sakurai and Edit Buz{\'a}s and P{\'e}ter Kov{\'a}cs and Gy{\"o}rgy Csaba and {\'A}gnes Kittel and Mikiko Okada and Masahiro Hara and Lynn Mar and Keiko Numayama-Tsuruta and Satsuki Ishigaki-Suzuki and Kazuo Ohuchi and Atsushi Ichikawa and Andr{\'a}s Falus and Takehiko Watanabe and Andr{\'a}s Nagy",

note = "Funding Information: This work was supported by Grants-in-Aid form the Ministry of Education, Science and Culture of Japan and grants form the Mochida Memorial Foundation for Medical and Pharmaceutical Research and the Kanae Foundation for Life and Socio-Medical Science. The authors are grateful to Drs. Alan Bernstein, Sharon Cunningham, Janet Rossant, Kathy Siminovitch, and Jody Haigh for critical reading of the manuscript, Dr. Zsuzsa T{\"o}m{\"o}sk{\"o}zi for her excellent preliminary studies, Judy Pawling for exceptional technical assistance, Dezs{\"o} Szab{\'o} for microscopic photography and George Dobrean for the art work.",

year = "2001",

month = jul,

day = "27",

doi = "10.1016/S0014-5793(01)02663-1",

language = "English",

volume = "502",

pages = "53--56",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Wiley-Blackwell",

number = "1-2",

}

Ohtsu, H, Tanaka, S, Terui, T, Hori, Y, Makabe-Kobayashi, Y, Pejler, G, Tchougounova, E, Hellman, L, Gertsenstein, M, Hirasawa, N, Sakurai, E, Buzás, E, Kovács, P, Csaba, G, Kittel, Á, Okada, M, Hara, M, Mar, L, Numayama-Tsuruta, K, Ishigaki-Suzuki, S, Ohuchi, K, Ichikawa, A, Falus, A, Watanabe, T & Nagy, A 2001, 'Mice lacking histidine decarboxylase exhibit abnormal mast cells', FEBS Letters, vol. 502, no. 1-2, pp. 53-56. https://doi.org/10.1016/S0014-5793(01)02663-1

TY - JOUR

T1 - Mice lacking histidine decarboxylase exhibit abnormal mast cells

AU - Ohtsu, Hiroshi

AU - Tanaka, Satoshi

AU - Terui, Tadashi

AU - Hori, Yoshio

AU - Makabe-Kobayashi, Yoko

AU - Pejler, Gunnar

AU - Tchougounova, Elena

AU - Hellman, Lars

AU - Gertsenstein, Marina

AU - Hirasawa, Noriyasu

AU - Sakurai, Eiko

AU - Buzás, Edit

AU - Kovács, Péter

AU - Csaba, György

AU - Kittel, Ágnes

AU - Okada, Mikiko

AU - Hara, Masahiro

AU - Mar, Lynn

AU - Numayama-Tsuruta, Keiko

AU - Ishigaki-Suzuki, Satsuki

AU - Ohuchi, Kazuo

AU - Ichikawa, Atsushi

AU - Falus, András

AU - Watanabe, Takehiko

AU - Nagy, András

N1 - Funding Information: This work was supported by Grants-in-Aid form the Ministry of Education, Science and Culture of Japan and grants form the Mochida Memorial Foundation for Medical and Pharmaceutical Research and the Kanae Foundation for Life and Socio-Medical Science. The authors are grateful to Drs. Alan Bernstein, Sharon Cunningham, Janet Rossant, Kathy Siminovitch, and Jody Haigh for critical reading of the manuscript, Dr. Zsuzsa Tömösközi for her excellent preliminary studies, Judy Pawling for exceptional technical assistance, Dezsö Szabó for microscopic photography and George Dobrean for the art work.

PY - 2001/7/27

Y1 - 2001/7/27

N2 - Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC-deficient mice using a gene targeting method. The mice showed a histamine deficiency and lacked histamine-synthesizing activity from histidine. These HDC-deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content. The amounts of mast cell granular proteases were tremendously reduced. The HDC-deficient mice provide a unique and promising model for studying the role of histamine in a broad range of normal and disease processes.

AB - Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC-deficient mice using a gene targeting method. The mice showed a histamine deficiency and lacked histamine-synthesizing activity from histidine. These HDC-deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content. The amounts of mast cell granular proteases were tremendously reduced. The HDC-deficient mice provide a unique and promising model for studying the role of histamine in a broad range of normal and disease processes.

KW - Histamine

KW - Knockout

KW - Mast cell

KW - Rodent

UR - http://www.scopus.com/inward/record.url?scp=0035958707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035958707&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(01)02663-1

DO - 10.1016/S0014-5793(01)02663-1

M3 - Article

C2 - 11478947

AN - SCOPUS:0035958707

SN - 0014-5793

VL - 502

SP - 53

EP - 56

JO - FEBS Letters

JF - FEBS Letters

IS - 1-2

ER -

Mice lacking histidine decarboxylase exhibit abnormal mast cells

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this