Microelectrochemical Approach to Induce Local Cell Adhesion and Growth on Substrates

Hirokazu Kaji, Masamitsu Kanada, Daisuke Oyamatsu, Tomokazu Matsue, Matsuhiko Nishizawa

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)


The nature of an albumin-coated substrate that blocks protein adsorption and cell adhesion was rapidly switched to cell-adhesive by exposure to an oxidizing agent such as HBrO. This finding has enabled cellular pattern drawing even on a single-cell level by closely scanning a microelectrode above the substrate and electrochemically producing the agent at the tip of the electrode. The present microelectrochemical cell patterning is applicable even for a previously cell-patterned substrate and for a grooved substrate. These unique technical features will have impacts on a variety of cell-based studies that require the analysis of heterotypic cell-cell interactions and cellular arrangement on an uneven surface such as semiconductor devices.

Original languageEnglish
Pages (from-to)16-19
Number of pages4
Issue number1
Publication statusPublished - 2004 Jan 6


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