Micro/nano-patterned surfaces for control of cell adhesion and cell functions: Differentiation into adipocytes

Makiko Goto; Kae Sato; Takehiko Tsukahara; Tomohiro Konno; Kazuhiko Ishihara; Takehiko Kitamori

Micro/nano-patterned surfaces for control of cell adhesion and cell functions: Differentiation into adipocytes

Makiko Goto, Kae Sato, Takehiko Tsukahara, Tomohiro Konno, Kazuhiko Ishihara, Takehiko Kitamori

PHA - Molecular Pharmaceutical Science

Research output: Contribution to conference › Paper › peer-review

1 Citation (Scopus)

Abstract

Cell adhesion surfaces having micro/nano patterns and controlled chemical properties were fabricated. The patterning at a subcellular-scale should control the formation of focal adhesion formation that plays an important role in many cellular functions. We observed that preadipocytes adhered, proliferated on the surfaces, and were induced to differentiate. Individual cells adhered and grew on the patterns but confluent cell monolayers on nano patterns easily detached from the substrata. The micro/nano patterns provide cells with unique scaffolds controlling cell-matrix interactions at a subcellular scale.

Original language	English
Pages	993-995
Number of pages	3
Publication status	Published - 2006
Event	10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan Duration: 2006 Nov 5 → 2006 Nov 9

Conference

Conference	10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
Country/Territory	Japan
City	Tokyo
Period	06/11/5 → 06/11/9

Keywords

Cell adhesion
Cell differentiation
Nano patterning

Cite this

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title = "Micro/nano-patterned surfaces for control of cell adhesion and cell functions: Differentiation into adipocytes",

abstract = "Cell adhesion surfaces having micro/nano patterns and controlled chemical properties were fabricated. The patterning at a subcellular-scale should control the formation of focal adhesion formation that plays an important role in many cellular functions. We observed that preadipocytes adhered, proliferated on the surfaces, and were induced to differentiate. Individual cells adhered and grew on the patterns but confluent cell monolayers on nano patterns easily detached from the substrata. The micro/nano patterns provide cells with unique scaffolds controlling cell-matrix interactions at a subcellular scale.",

keywords = "Cell adhesion, Cell differentiation, Nano patterning",

author = "Makiko Goto and Kae Sato and Takehiko Tsukahara and Tomohiro Konno and Kazuhiko Ishihara and Takehiko Kitamori",

year = "2006",

language = "English",

pages = "993--995",

note = "10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 ; Conference date: 05-11-2006 Through 09-11-2006",

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Micro/nano-patterned surfaces for control of cell adhesion and cell functions: Differentiation into adipocytes. / Goto, Makiko; Sato, Kae; Tsukahara, Takehiko et al.
2006. 993-995 Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.

Research output: Contribution to conference › Paper › peer-review

TY - CONF

T1 - Micro/nano-patterned surfaces for control of cell adhesion and cell functions

T2 - 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006

AU - Goto, Makiko

AU - Sato, Kae

AU - Tsukahara, Takehiko

AU - Konno, Tomohiro

AU - Ishihara, Kazuhiko

AU - Kitamori, Takehiko

PY - 2006

Y1 - 2006

N2 - Cell adhesion surfaces having micro/nano patterns and controlled chemical properties were fabricated. The patterning at a subcellular-scale should control the formation of focal adhesion formation that plays an important role in many cellular functions. We observed that preadipocytes adhered, proliferated on the surfaces, and were induced to differentiate. Individual cells adhered and grew on the patterns but confluent cell monolayers on nano patterns easily detached from the substrata. The micro/nano patterns provide cells with unique scaffolds controlling cell-matrix interactions at a subcellular scale.

AB - Cell adhesion surfaces having micro/nano patterns and controlled chemical properties were fabricated. The patterning at a subcellular-scale should control the formation of focal adhesion formation that plays an important role in many cellular functions. We observed that preadipocytes adhered, proliferated on the surfaces, and were induced to differentiate. Individual cells adhered and grew on the patterns but confluent cell monolayers on nano patterns easily detached from the substrata. The micro/nano patterns provide cells with unique scaffolds controlling cell-matrix interactions at a subcellular scale.

KW - Cell adhesion

KW - Cell differentiation

KW - Nano patterning

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M3 - Paper

AN - SCOPUS:84902455866

SP - 993

EP - 995

Y2 - 5 November 2006 through 9 November 2006

ER -

Micro/nano-patterned surfaces for control of cell adhesion and cell functions: Differentiation into adipocytes

Abstract

Conference

Keywords

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