Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer

Toshinori Fujie; Yoshihiro Mori; Shuntaro Ito; Matsuhiko Nishizawa; Hojae Bae; Nobuhiro Nagai; Hideyuki Onami; Toshiaki Abe; Ali Khademhosseini; Hirokazu Kaji

doi:10.1002/adma.201304183

Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer

Toshinori Fujie, Yoshihiro Mori, Shuntaro Ito, Matsuhiko Nishizawa, Hojae Bae, Nobuhiro Nagai, Hideyuki Onami, Toshiaki Abe, Ali Khademhosseini, Hirokazu Kaji

ENG - Finemechanics

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Like a carpet for cells, micropatterned polymeric nanosheets are developed toward local cell delivery. The nanosheets direct morphogenesis of retinal pigment epithelial (RPE) cells and allow for the injection of an engineered RPE monolayer through syringe needles without the loss of cell viability. Such an ultrathin carrier has the promise of a minimally invasive delivery of cells into narrow tissue spaces.

Original language	English
Pages (from-to)	1699-1705
Number of pages	7
Journal	Advanced Materials
Volume	26
Issue number	11
DOIs	https://doi.org/10.1002/adma.201304183
Publication status	Published - 2014 Mar 19

Keywords

cell delivery
magnetic nanoparticles (MNP)
retinal pigment epithelium (RPE)
tight junctions
ultrathin films (nanosheets)

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10.1002/adma.201304183

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abstract = "Like a carpet for cells, micropatterned polymeric nanosheets are developed toward local cell delivery. The nanosheets direct morphogenesis of retinal pigment epithelial (RPE) cells and allow for the injection of an engineered RPE monolayer through syringe needles without the loss of cell viability. Such an ultrathin carrier has the promise of a minimally invasive delivery of cells into narrow tissue spaces.",

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AU - Fujie, Toshinori

AU - Mori, Yoshihiro

AU - Ito, Shuntaro

AU - Nishizawa, Matsuhiko

AU - Bae, Hojae

AU - Nagai, Nobuhiro

AU - Onami, Hideyuki

AU - Abe, Toshiaki

AU - Khademhosseini, Ali

AU - Kaji, Hirokazu

PY - 2014/3/19

Y1 - 2014/3/19

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AB - Like a carpet for cells, micropatterned polymeric nanosheets are developed toward local cell delivery. The nanosheets direct morphogenesis of retinal pigment epithelial (RPE) cells and allow for the injection of an engineered RPE monolayer through syringe needles without the loss of cell viability. Such an ultrathin carrier has the promise of a minimally invasive delivery of cells into narrow tissue spaces.

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KW - magnetic nanoparticles (MNP)

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KW - tight junctions

KW - ultrathin films (nanosheets)

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Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer

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Keywords

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