Mimicking multipass transmembrane proteins: Synthesis, assembly and folding of alternating amphiphilic multiblock molecules in liposomal membranes

Takahiro Muraoka; Tatsuya Shima; Tsutomu Hamada; Masamune Morita; Masahiro Takagi; Kazushi Kinbara

doi:10.1039/c0cc02420a

Mimicking multipass transmembrane proteins: Synthesis, assembly and folding of alternating amphiphilic multiblock molecules in liposomal membranes

Takahiro Muraoka, Tatsuya Shima, Tsutomu Hamada, Masamune Morita, Masahiro Takagi, Kazushi Kinbara

Institute of Multidisciplinary Research for Advanced Materials (IMRAM)

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Alternating amphiphilic multiblock molecules 1–4, involving fluorescent hydrophobic units, were designed as mimics for multipass transmembrane proteins. Fluorescence spectroscopy of 1–4 in liposomal membranes suggested the face-to-face stacking of the hydrophobic units to give folded structures as well as intermolecular assemblies.

Original language	English
Pages (from-to)	194-196
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	1
DOIs	https://doi.org/10.1039/c0cc02420a
Publication status	Published - 2011 Dec 6

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c0cc02420a

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AU - Takagi, Masahiro

AU - Kinbara, Kazushi

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Mimicking multipass transmembrane proteins: Synthesis, assembly and folding of alternating amphiphilic multiblock molecules in liposomal membranes

Abstract

ASJC Scopus subject areas

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