Model-based background compensation for repeat PET study with multiple tracer administration

Hidehiro Iida, Hiroshi Watabe, Takuya Hayashi, Nobuyuki Kudomi, Keyong Min Kim

Research output: Contribution to journalConference articlepeer-review


A method has been developed for repeat quantitation of physiological parameters from multiple administrations of radiotracers. The background activity distribution due to the previous tracer administration was formulated according to a compartment model, so as to allow initiation of the next scan while residual radioactivity exists, minimizing the intervals between scans, with the minimum enhancement of the statistical noise. Theoretical simulation for repeat administration of H215O demonstrated that the transient tracer distribution was highly weighted on transient rCBF immediately after the previous tracer administration, and that the change of rCBF after a certain period has only small contribution to the estimated tracer distributions. Another set of simulation showed that estimated rCBF was sensitive to the transient rCBF only immediately after the tracer administration, and that the change after a certain period does not contribute to the rCBF estimated by the present approach. This technique was then applied to a clinical study of serial administration of H215O and 15O2 and demonstrated that the yielded CBF and CMRO2 are well agreed with those determined based on the classical 3-step measurements. We thus conclude that quantitation of physiological parameters can be determined by PET with much shorter examination interval as compared with the previous study protocol.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
Issue number15
Publication statusPublished - 2003
Event5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003 - Melbourne, Australia
Duration: 2003 Aug 212003 Aug 23


  • Compartment modelling
  • Multiple tracers
  • Regional cerebral blood flow
  • Single-photon emission computed tomography


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