Modification of single sodium channels by the insecticide tetramethrin

Daisuke Yamamoto; Fred N. Quandt; Toshio Narahashi

doi:10.1016/0006-8993(83)90716-3

Modification of single sodium channels by the insecticide tetramethrin

Daisuke Yamamoto, Fred N. Quandt, Toshio Narahashi

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

(+)-trans-Tetramethrin, a pyrethroid insecticide, markedly prolongs the open time of single sodium channels recorded by the gigaohm-seal voltage clamp technique in a membrane patch excised from the N1E-115 neuroblastoma cell. Single channel conductance is not altered by tetramethrin. The modification by tetramethrin occurs in an all-or-none manner in a population of sodium channels. The observed tetramethrin-induced modification of single sodium channels is compatible with previous sodium current data from axons.

Original language	English
Pages (from-to)	344-349
Number of pages	6
Journal	Brain research
Volume	274
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(83)90716-3
Publication status	Published - 1983 Sept 12
Externally published	Yes

Keywords

insecticide tetramethrin
neuroblastoma
patch clamp
pyrethroid
sodium channel

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(83)90716-3

Cite this

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title = "Modification of single sodium channels by the insecticide tetramethrin",

abstract = "(+)-trans-Tetramethrin, a pyrethroid insecticide, markedly prolongs the open time of single sodium channels recorded by the gigaohm-seal voltage clamp technique in a membrane patch excised from the N1E-115 neuroblastoma cell. Single channel conductance is not altered by tetramethrin. The modification by tetramethrin occurs in an all-or-none manner in a population of sodium channels. The observed tetramethrin-induced modification of single sodium channels is compatible with previous sodium current data from axons.",

keywords = "insecticide tetramethrin, neuroblastoma, patch clamp, pyrethroid, sodium channel",

author = "Daisuke Yamamoto and Quandt, {Fred N.} and Toshio Narahashi",

note = "Funding Information: We thank Dr. H. Yoshioka of Sumitomo Chemical Company for his generous supply of tetramethrin samples. Thanks are also due to Mary Taft and Randy Reid for technical assistance, and Janet Hender-son, Terri Warren and Veronica L. Whatley for secretarial assistance. This work was supported by NIH Grant NS14143.",

year = "1983",

month = sep,

day = "12",

doi = "10.1016/0006-8993(83)90716-3",

language = "English",

volume = "274",

pages = "344--349",

journal = "Molecular Brain Research",

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T1 - Modification of single sodium channels by the insecticide tetramethrin

AU - Yamamoto, Daisuke

AU - Quandt, Fred N.

AU - Narahashi, Toshio

N1 - Funding Information: We thank Dr. H. Yoshioka of Sumitomo Chemical Company for his generous supply of tetramethrin samples. Thanks are also due to Mary Taft and Randy Reid for technical assistance, and Janet Hender-son, Terri Warren and Veronica L. Whatley for secretarial assistance. This work was supported by NIH Grant NS14143.

PY - 1983/9/12

Y1 - 1983/9/12

N2 - (+)-trans-Tetramethrin, a pyrethroid insecticide, markedly prolongs the open time of single sodium channels recorded by the gigaohm-seal voltage clamp technique in a membrane patch excised from the N1E-115 neuroblastoma cell. Single channel conductance is not altered by tetramethrin. The modification by tetramethrin occurs in an all-or-none manner in a population of sodium channels. The observed tetramethrin-induced modification of single sodium channels is compatible with previous sodium current data from axons.

AB - (+)-trans-Tetramethrin, a pyrethroid insecticide, markedly prolongs the open time of single sodium channels recorded by the gigaohm-seal voltage clamp technique in a membrane patch excised from the N1E-115 neuroblastoma cell. Single channel conductance is not altered by tetramethrin. The modification by tetramethrin occurs in an all-or-none manner in a population of sodium channels. The observed tetramethrin-induced modification of single sodium channels is compatible with previous sodium current data from axons.

KW - insecticide tetramethrin

KW - neuroblastoma

KW - patch clamp

KW - pyrethroid

KW - sodium channel

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Modification of single sodium channels by the insecticide tetramethrin

Abstract

Keywords

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