Modification of single sodium channels by the insecticide tetramethrin

Daisuke Yamamoto, Fred N. Quandt, Toshio Narahashi

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


(+)-trans-Tetramethrin, a pyrethroid insecticide, markedly prolongs the open time of single sodium channels recorded by the gigaohm-seal voltage clamp technique in a membrane patch excised from the N1E-115 neuroblastoma cell. Single channel conductance is not altered by tetramethrin. The modification by tetramethrin occurs in an all-or-none manner in a population of sodium channels. The observed tetramethrin-induced modification of single sodium channels is compatible with previous sodium current data from axons.

Original languageEnglish
Pages (from-to)344-349
Number of pages6
JournalBrain research
Issue number2
Publication statusPublished - 1983 Sept 12
Externally publishedYes


  • insecticide tetramethrin
  • neuroblastoma
  • patch clamp
  • pyrethroid
  • sodium channel

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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